M
Martin Komosa
Researcher at University of Toronto
Publications - 19
Citations - 734
Martin Komosa is an academic researcher from University of Toronto. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 9, co-authored 12 publications receiving 490 citations.
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Journal ArticleDOI
A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal
Michael Milyavsky,Michael Milyavsky,Olga I. Gan,Olga I. Gan,Magan Trottier,Martin Komosa,Ofer Tabach,Faiyaz Notta,Faiyaz Notta,Eric R. Lechman,Eric R. Lechman,Karin G. Hermans,Karin G. Hermans,Kolja Eppert,Kolja Eppert,Zhanna Konovalova,Zhanna Konovalova,Olga Ornatsky,Eytan Domany,M. Stephen Meyn,John E. Dick,John E. Dick +21 more
TL;DR: The data reveal distinct physiological roles of p53 that together ensure optimal HSC function: apoptosis regulation and prevention of gammaH2AX foci accumulation upon HSC self-renewal.
Journal ArticleDOI
Locoregional delivery of CAR T cells to the cerebrospinal fluid for treatment of metastatic medulloblastoma and ependymoma
Laura K. Donovan,Alberto Delaidelli,Sujith K. Joseph,Kevin Bielamowicz,Kristen Fousek,Borja L. Holgado,Alex Manno,Dilakshan Srikanthan,Ahmed Z. Gad,Randy Van Ommeren,David Przelicki,Cory Richman,Vijay Ramaswamy,Craig Daniels,Jonelle G. Pallota,Tajana Douglas,Alyssa C. M. Joynt,Joonas Haapasalo,Carolina Nor,Maria C. Vladoiu,Claudia M. Kuzan-Fischer,Livia Garzia,Stephen C. Mack,Srinidhi Varadharajan,Matthew L. Baker,Liam D. Hendrikse,Michelle Ly,Kaitlin Kharas,Polina Balin,Xiaochong Wu,Lei Qin,Ning Huang,Ana Guerreiro Stucklin,A. Sorana Morrissy,Florence M.G. Cavalli,Betty Luu,Raul Suarez,Pasqualino De Antonellis,Antony Michealraj,Avesta Rastan,Meenakshi Hegde,Martin Komosa,Olga Sirbu,Sachin Kumar,Zied Abdullaev,Claudia C. Faria,Stephen Yip,Juliette Hukin,Uri Tabori,Cynthia Hawkins,Kenneth Aldape,Mads Daugaard,Mads Daugaard,John M. Maris,John M. Maris,Poul H. Sorensen,Nabil Ahmed,Michael D. Taylor +57 more
TL;DR: It is demonstrated that administration of these chimeric antigen receptor T cells into the cerebrospinal fluid, alone or in combination with azacytidine, is a highly effective therapy for multiple metastatic mouse models of group 3 medulloblastoma and PFA ependymoma, thereby providing a rationale for clinical trials of these approaches in humans.
Journal ArticleDOI
DNA hypermethylation within TERT promoter upregulates TERT expression in cancer
Donghyun Lee,Ricardo Leão,Ricardo Leão,Martin Komosa,Marco Gallo,Cindy Zhang,Tatiana Lipman,Marc Remke,Abolfazl Heidari,Nuno Miguel Nunes,Joana Dias Apolónio,Aryeh J. Price,Ramon Andrade de Mello,João S. Dias,David G. Huntsman,Thomas Hermanns,Peter J. Wild,Robert Vanner,Gelareh Zadeh,Jason Karamchandani,Sunit Das,Michael D. Taylor,Cynthia Hawkins,Jonathan D. Wasserman,Arnaldo Figueiredo,Robert J. Hamilton,Mark D. Minden,Khalida Wani,Bill H. Diplas,Hai Yan,Kenneth Aldape,Mohammad R. Akbari,Arnavaz Danesh,Trevor J. Pugh,Peter B. Dirks,Pedro Castelo-Branco,Uri Tabori +36 more
TL;DR: It is proposed that THORhypermethylation is a prevalent telomerase-activating mechanism in cancer that can act independently of or in conjunction with TPMs, further supporting the utility of THOR hypermethylation as a prognostic biomarker.
Journal ArticleDOI
K63-Ubiquitylation of VHL by SOCS1 mediates DNA double-strand break repair
TL;DR: It is shown that suppressor of cytokine signaling 1 (SOCS1) promotes nuclear redistribution and K63-ubiquitylation of VHL in response to DNA double-strand breaks (DSBs), and inactivation of which contributes to the genomic instability associated with CCRCC.
Journal ArticleDOI
Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer.
Ricardo Leão,Donghyun Lee,Arnaldo Figueiredo,Thomas Hermanns,Peter J. Wild,Martin Komosa,Irene Lau,Mathew Mistry,Nuno Miguel Nunes,Aryeh J. Price,Cindy Zhang,Tatiana Lipman,Cédric Poyet,Nadejda Valtcheva,Kathrin Oehl,Hugo Coelho,Rashid K. Sayyid,Ana Melo Gomes,Lígia Prado e Castro,Joan Sweet,João Vinagre,Joana Dias Apolónio,Derek Stephens,Inês Faleiro,Kamel Fadaak,Kamel Fadaak,Patrick O. Richard,Patrick O. Richard,Girish S. Kulkarni,Alexandre R. Zlotta,Robert J. Hamilton,Pedro Castelo-Branco,Uri Tabori +32 more
TL;DR: The results highlight that both mechanisms are common and coexist in bladder cancer and while TERTpMut is an early event in bladder carcinogenesis THOR hypermethylation is a dynamic process that contributes to disease progression.