N
Naoya Takayama
Researcher at Princess Margaret Cancer Centre
Publications - 11
Citations - 1359
Naoya Takayama is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 6, co-authored 11 publications receiving 1059 citations. Previous affiliations of Naoya Takayama include Ontario Institute for Cancer Research & University of Toronto.
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Journal ArticleDOI
Distinct routes of lineage development reshape the human blood hierarchy across ontogeny
Faiyaz Notta,Faiyaz Notta,Sasan Zandi,Sasan Zandi,Naoya Takayama,Naoya Takayama,Stephanie M. Dobson,Stephanie M. Dobson,Olga I. Gan,Gavin W. Wilson,Gavin W. Wilson,Kerstin B. Kaufmann,Kerstin B. Kaufmann,Jessica McLeod,Elisa Laurenti,Cyrille F. Dunant,John Douglas Mcpherson,John Douglas Mcpherson,Lincoln Stein,Lincoln Stein,Yigal Dror,John E. Dick,John E. Dick +22 more
TL;DR: Using a cell-sorting scheme based on markers linked to Er and Mk lineage specification, it is found that previously described populations of multipotent progenitors (MPPs), CMPs, and megakaryocyte-erythroid progenitor (MEPs) were heterogeneous and could be further purified.
Journal ArticleDOI
A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies.
Carsten Bahr,Carsten Bahr,Lisa von Paleske,Lisa von Paleske,Veli Vural Uslu,Silvia Remeseiro,Naoya Takayama,Naoya Takayama,Stanley W.K. Ng,Alex Murison,Alex Murison,Katja Langenfeld,Massimo Petretich,Roberta Scognamiglio,Roberta Scognamiglio,Petra Zeisberger,Amelie S. Benk,Amelie S. Benk,Ido Amit,Peter W. Zandstra,Mathieu Lupien,Mathieu Lupien,John E. Dick,John E. Dick,Andreas Trumpp,François Spitz,François Spitz +26 more
TL;DR: It is proposed that clusters of enhancers form highly combinatorial systems that allow precise control of gene expression across normal cellular hierarchies and which also can be hijacked in malignancies.
Journal ArticleDOI
miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells
Eric R. Lechman,Eric R. Lechman,Bernhard Gentner,Stanley W.K. Ng,Erwin M. Schoof,Erwin M. Schoof,Peter van Galen,Peter van Galen,James A. Kennedy,James A. Kennedy,Silvia Nucera,Fabio Ciceri,Kerstin B. Kaufmann,Kerstin B. Kaufmann,Naoya Takayama,Naoya Takayama,Stephanie M. Dobson,Stephanie M. Dobson,Aaron Trotman-Grant,Aaron Trotman-Grant,Gabriela Krivdova,Gabriela Krivdova,Janneke Elzinga,Janneke Elzinga,Amanda Mitchell,Amanda Mitchell,Björn Nilsson,Karin G. Hermans,Karin G. Hermans,Kolja Eppert,Rene Marke,Ruth Isserlin,Veronique Voisin,Gary D. Bader,Peter W. Zandstra,Todd R. Golub,Benjamin L. Ebert,Jun Lu,Mark D. Minden,Mark D. Minden,Jean C.Y. Wang,Jean C.Y. Wang,Luigi Naldini,John E. Dick,John E. Dick +44 more
TL;DR: Combined transcriptome and proteome analysis demonstrates that miR-126 targets the PI3K/AKT/MTOR signaling pathway, preserving LSC quiescence and promoting chemotherapy resistance.
Journal ArticleDOI
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Satoshi Inoue,Satoshi Inoue,Wanda Y. Li,Wanda Y. Li,Alan Tseng,Alan Tseng,Alan Tseng,Isabel Beerman,Isabel Beerman,Andrew J. Elia,Andrew J. Elia,Sean C. Bendall,François Lemonnier,François Lemonnier,Ken Kron,Ken Kron,David W. Cescon,David W. Cescon,Zhenyue Hao,Zhenyue Hao,Evan F. Lind,Evan F. Lind,Naoya Takayama,Aline Cristiane Planello,Aline Cristiane Planello,Aline Cristiane Planello,Shu Yi Shen,Shu Yi Shen,Alan H. Shih,Dana M. Larsen,Qinxi Li,Qinxi Li,Bryan E. Snow,Bryan E. Snow,Andrew Wakeham,Andrew Wakeham,Jillian Haight,Jillian Haight,Chiara Gorrini,Chiara Gorrini,Christian Bassi,Christian Bassi,Kelsie L. Thu,Kelsie L. Thu,Kiichi Murakami,Kiichi Murakami,Alisha R. Elford,Alisha R. Elford,Takeshi Ueda,Takeshi Ueda,Kimberly Straley,Katharine E. Yen,Gerry Melino,Gerry Melino,Luisa Cimmino,Iannis Aifantis,Ross L. Levine,Daniel D. De Carvalho,Daniel D. De Carvalho,Mathieu Lupien,Mathieu Lupien,Derrick J. Rossi,Garry P. Nolan,Rob A. Cairns,Rob A. Cairns,Tak W. Mak,Tak W. Mak,Tak W. Mak +67 more
TL;DR: It is discovered that mice expressing endogenous mutant IDH1 have reduced numbers of hematopoietic stem cells (HSCs) in contrast to Tet2 knockout (TET2-KO) mice, which may have implications for treatment of IDH-mutant leukemia.
Journal ArticleDOI
MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin.
Marco Gallo,Fiona J. Coutinho,Robert Vanner,Tenzin Gayden,Stephen C. Mack,Stephen C. Mack,Alex Murison,Marc Remke,Ren Li,Naoya Takayama,Kinjal Desai,Lilian Lee,Xiaoyang Lan,Nicole I. Park,Dalia Barsyte-Lovejoy,Dalia Barsyte-Lovejoy,David Smil,David Smil,Dominik Sturm,Michelle Kushida,Renee Head,Michael D. Cusimano,Michael D. Cusimano,Mark Bernstein,Mark Bernstein,Ian D. Clarke,John E. Dick,Stefan M. Pfister,Jeremy N. Rich,Cheryl H. Arrowsmith,Cheryl H. Arrowsmith,Michael D. Taylor,Nada Jabado,David P. Bazett-Jones,Mathieu Lupien,Mathieu Lupien,Peter B. Dirks +36 more
TL;DR: This work uncovers a role for MLL5 and H3.3 in maintaining self-renewal hierarchies in adult GBM, and exploited these epigenetic states to rationally identify two small molecules that effectively curb cancer stem cell properties in a preclinical model.