K
Karin M Danzer
Researcher at University of Ulm
Publications - 73
Citations - 6258
Karin M Danzer is an academic researcher from University of Ulm. The author has contributed to research in topics: Alpha-synuclein & Amyotrophic lateral sclerosis. The author has an hindex of 31, co-authored 65 publications receiving 5168 citations. Previous affiliations of Karin M Danzer include German Center for Neurodegenerative Diseases & Harvard University.
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Journal ArticleDOI
Exosomal cell-to-cell transmission of alpha synuclein oligomers
Karin M Danzer,Karin M Danzer,Lisa R. Kranich,Wolfgang Ruf,Ozge Cagsal-Getkin,Ashley R. Winslow,Liya Zhu,Charles R. Vanderburg,Pamela J. McLean,Pamela J. McLean +9 more
TL;DR: The data suggest that αsyn may be secreted via different secretory pathways, and hypothesize that exosome-mediated release of αsyn oligomers is a mechanism whereby cells clear toxic α synuclein oligomers when autophagic mechanisms fail to be sufficient.
Journal ArticleDOI
Different Species of α-Synuclein Oligomers Induce Calcium Influx and Seeding
Karin M Danzer,Dorothea Haasen,Anne R. Karow,Simon Moussaud,Matthias Habeck,Armin Giese,Hans A. Kretzschmar,Bastian Hengerer,Marcus Kostka +8 more
TL;DR: The data indicate that inhibition of early α- syn aggregation events would consequently prevent all α-syn oligomer related toxicities, which has important implications for the development of disease-modifying drugs for the treatment of PD and other synucleinopathies.
Journal ArticleDOI
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
Axel Freischmidt,Thomas Wieland,Benjamin Richter,Wolfgang Ruf,Veronique Schaeffer,Kathrin Muller,Nicolai Marroquin,Frida Nordin,Annemarie Hübers,Patrick Weydt,Susana Pinto,Rayomond Press,Stéphanie Millecamps,Nicolas Molko,Emilien Bernard,Claude Desnuelle,Marie-Hélène Soriani,Johannes Dorst,Elisabeth Graf,Ulrika Nordström,Marisa S. Feiler,Stefan Putz,Tobias M. Boeckers,Thomas F. Meyer,Andrea Sylvia Winkler,Juliane Winkelman,Mamede de Carvalho,Dietmar Rudolf Thal,Markus Otto,Thomas Brännström,Alexander E Volk,Petri Kursula,Karin M Danzer,Peter Lichtner,Ivan Dikic,Thomas Meitinger,Albert C. Ludolph,Tim M. Strom,Peter M Andersen,Jochen H. Weishaupt +39 more
TL;DR: It is concluded that haploinsufficiency of TBK1 causes ALS and fronto-temporal dementia.
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Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies
Anne Stuendl,Marcel Kunadt,Niels Kruse,Claudia Bartels,Wiebke Moebius,Karin M Danzer,Brit Mollenhauer,Anja Schneider +7 more
TL;DR: CSF exosomes of patients with Parkinson’s disease or dementia with Lewy bodies contain α- synuclein and induce α-synuclein aggregation in a reporter cell line, indicating that exosome support may support inter-neuronal transmission of α- Synuclein pathology.
Journal ArticleDOI
Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity
Karin M Danzer,Wolfgang Ruf,Preeti Putcha,Daniel Joyner,Tadafumi Hashimoto,Charles G. Glabe,Bradley T. Hyman,Pamela J. McLean +7 more
TL;DR: In a cellular model, the presence of αsyn oligomers in the extracellular space, their uptake by neurons, retrograde axonal transport to cell soma, and detrimental effects on neighboring cells are demonstrated and their modulation by Hsp70 represents a potential new target for therapeutic interventions.