M
Marcel Kunadt
Researcher at Max Planck Society
Publications - 4
Citations - 448
Marcel Kunadt is an academic researcher from Max Planck Society. The author has contributed to research in topics: Endosome & Proteome. The author has an hindex of 2, co-authored 3 publications receiving 356 citations. Previous affiliations of Marcel Kunadt include University of Göttingen.
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Journal ArticleDOI
Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies
Anne Stuendl,Marcel Kunadt,Niels Kruse,Claudia Bartels,Wiebke Moebius,Karin M Danzer,Brit Mollenhauer,Anja Schneider +7 more
TL;DR: CSF exosomes of patients with Parkinson’s disease or dementia with Lewy bodies contain α- synuclein and induce α-synuclein aggregation in a reporter cell line, indicating that exosome support may support inter-neuronal transmission of α- Synuclein pathology.
Journal ArticleDOI
Extracellular vesicle sorting of α-Synuclein is regulated by sumoylation
Marcel Kunadt,Katrin Eckermann,Anne Stuendl,Jing Gong,Jing Gong,Belisa Russo,Belisa Russo,Katrin Strauss,Surya Rai,Sebastian Kügler,Lisandro J. Falomir Lockhart,Martin Schwalbe,Petranka Krumova,Luís M. A. Oliveira,Mathias Bähr,Wiebke Möbius,Johannes Levin,Armin Giese,Niels Kruse,Brit Mollenhauer,Ruth Geiss-Friedlander,Albert C. Ludolph,Axel Freischmidt,Marisa S. Feiler,Karin M Danzer,Markus Zweckstetter,Markus Zweckstetter,Thomas M. Jovin,Mikael Simons,Jochen H. Weishaupt,Anja Schneider +30 more
TL;DR: The study reveals a function of SUMO protein modification as a Ubiquitin-independent ESCRT sorting signal, regulating the extracellular vesicle release of α-Synuclein, and proposes that sumo-dependent sorting constitutes a mechanism with more general implications for cell biology.
Journal ArticleDOI
Evaluation of the methoxy-X04 derivative BSC4090 for diagnosis of prodromal and early Alzheimer’s disease from bioptic olfactory mucosa
Hannah Pellkofer,Friedrich Ihler,Bernhard G. Weiss,Janina Trothe,Janina Trothe,Harindranath Kadavath,Monika Chongtham,Marcel Kunadt,Dietmar Riedel,Finn Lornsen,Petra Wilken,Claudia Bartels,Sina Hirschel,Sebastian G. Russo,Elke Stransky,Lutz Trojan,Boris Schmidt,Eckhardt Mandelkow,Eckhardt Mandelkow,Eckhardt Mandelkow,Markus Zweckstetter,Markus Zweckstetter,Markus Zweckstetter,Martin Canis,Anja Schneider,Anja Schneider +25 more
TL;DR: Using NMR spectroscopy, it is found that BSC4090 binds to fibrillsar and pre-fibrillar but not to monomeric tau, suggesting it may be an interesting candidate to detect AD at the early disease stages.
Journal ArticleDOI
C1q is increased in cerebrospinal fluid-derived extracellular vesicles in Alzheimer's disease: A multi-cohort proteomics and immuno-assay validation study.
S. Chatterjee,Selçuk Özdemir,Marcel Kunadt,Marleen J. A. Koel-Simmelink,Lars Piepkorn,Thang V. Pham,Davide Chiasserini,Sander R. Piersma,Jaco C. Knol,Wiebke Möbius,Brit Mollenhauer,Wiesje M. van der Flier,Connie R. Jimenez,Charlotte E. Teunissen,Olaf Jahn,Anja Schneider +15 more
TL;DR: In this article , a comprehensive characterization of the proteome of extracellular vesicles (EVs) of cerebrospinal fluid (CSF) was performed to identify proteins and pathways altered in Alzheimer's disease (AD) pathology.