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Karla A. Lee
Researcher at King's College London
Publications - 40
Citations - 2758
Karla A. Lee is an academic researcher from King's College London. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 11, co-authored 34 publications receiving 1282 citations. Previous affiliations of Karla A. Lee include St Thomas' Hospital & Mount Vernon Hospital.
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Journal ArticleDOI
Risk of COVID-19 among front-line health-care workers and the general community: a prospective cohort study.
Long H. Nguyen,David A. Drew,Mark S. Graham,Amit Joshi,Chuan Guo Guo,Chuan Guo Guo,Wenjie Ma,Raaj S. Mehta,Erica T. Warner,Daniel Sikavi,Chun-Han Lo,Sohee Kwon,Mingyang Song,Lorelei A. Mucci,Meir J. Stampfer,Walter C. Willett,A. Heather Eliassen,Jaime E. Hart,Jorge E. Chavarro,Janet W. Rich-Edwards,Richard Davies,Joan Capdevila,Karla A. Lee,Mary Ni Lochlainn,Thomas Varsavsky,Carole H. Sudre,M. Jorge Cardoso,Jonathan Wolf,Tim D. Spector,Sebastien Ourselin,Claire J. Steves,Andrew T. Chan,Christine M. Albert,Gabriella Andreotti,Bijal Bala,Bijal A. Balasubramanian,Laura Beane-Freeman,John S. Brownstein,Fiona Bruinsma,Joe Coresh,Rui Costa,Annie Cowan,Anusila Deka,Sandra Deming-Halverson,Maria Elena Martinez,Michael E. Ernst,Jane C. Figueiredo,Pedro Fortuna,Paul W. Franks,Laura E. Beane Freeman,Christopher D. Gardner,Irene M. Ghobrial,Christopher A. Haiman,Janet E. Hall,Jae H. Kang,Brenda Kirpach,Karestan C. Koenen,Laura D. Kubzansky,James V. Lacey,Loic Le Marchand,Xihong Lin,Pamela L. Lutsey,Catherine R. Marinac,Roger L. Milne,Anne M. Murray,Denis Nash,Julie R. Palmer,Alpa V. Patel,Eric Pierce,McKaylee Robertson,Lynn Rosenberg,Dale P. Sandler,Shepherd H. Schurman,Kara Sewalk,Shreela V. Sharma,Chris Sidey-Gibbons,Liz Slevin,Jordan W. Smoller,Maarit Tiirikainen,Scott T. Weiss,Lynne R. Wilkens,Feng Zhang +81 more
TL;DR: In the UK and the USA, risk of reporting a positive test for COVID-19 was increased among front-line health-care workers, and adequacy of PPE, clinical setting, and ethnic background were also important factors.
Posted ContentDOI
Risk of symptomatic Covid-19 among frontline healthcare workers
Long H. Nguyen,David A. Drew,Amit Joshi,Chuan-Guo Guo,Wenjie Ma,Raaj S. Mehta,Daniel Sikavi,Chun-Han Lo,Sohee Kwon,Mingyang Song,Lorelei A. Mucci,Meir J. Stampfer,Walter C. Willett,A. Heather Eliassen,Jaime E. Hart,Jorge E. Chavarro,Janet W. Rich-Edwards,Richard Davies,Joan Capdevila,Karla A. Lee,Mary Ni Lochlainn,Thomas Varsavsky,Mark Graham,Carol H. Sudre,M. Jorge Cardoso,Jonathan Wolf,Sebastien Ourselin,Claire J. Steves,Tim D. Spector,Andrew T. Chan +29 more
TL;DR: Frontline HCWs had a significantly increased risk of COVID-19 infection, highest among HCWs who reused PPE or had inadequate access to PPE, however, adequate supplies of PPE did not completely mitigate high-risk exposures.
Posted ContentDOI
Symptom clusters in Covid19: A potential clinical prediction tool from the COVID Symptom study app
Carole H. Sudre,Karla A. Lee,Mary Ni Lochlainn,Thomas Varsavsky,Benjamin J. Murray,Mark Graham,Cristina Menni,Marc Modat,Ruth C. E. Bowyer,Long H. Nguyen,David A. Drew,Amit Joshi,Wenjie Ma,Chuan-Guo Guo,Chun-Han Lo,Sajaysurya Ganesh,Abubakar Buwe,Joan Capdevila Pujol,Julien Lavigne du Cadet,Alessia Visconti,Maxim B. Freidin,Julia S. El-Sayed Moustafa,Mario Falchi,Richard Davies,Maria F. Gomez,Tove Fall,M. Jorge Cardoso,Jonathan Wolf,Paul W. Franks,Paul W. Franks,Andrew T. Chan,Tim D. Spector,Claire J. Steves,Sebastien Ourselin +33 more
TL;DR: Unsupervised time series clustering over symptom presentation was performed on data collected from a training dataset of completed cases enlisted early from the COVID Symptom Study Smartphone application, yielding six distinct symptom presentations.
Journal ArticleDOI
Symptom clusters in COVID-19: A potential clinical prediction tool from the COVID Symptom Study app.
Carole H. Sudre,Carole H. Sudre,Karla A. Lee,Mary Ni Lochlainn,Thomas Varsavsky,Benjamin J. Murray,Mark S. Graham,Cristina Menni,Marc Modat,Ruth C. E. Bowyer,Long H. Nguyen,David A. Drew,Amit Joshi,Wenjie Ma,Chuan Guo Guo,Chun-Han Lo,Sajaysurya Ganesh,Abubakar Buwe,Joan Capdevila Pujol,Julien Lavigne du Cadet,Alessia Visconti,Maxim B. Freidin,Julia S. El-Sayed Moustafa,Mario Falchi,Richard Davies,Maria F. Gomez,Tove Fall,M. Jorge Cardoso,Jonathan Wolf,Paul W. Franks,Paul W. Franks,Andrew T. Chan,Tim D. Spector,Claire J. Steves,Sebastien Ourselin +34 more
TL;DR: In this article, an unsupervised time series clustering over symptom presentation was performed on data collected from a training dataset of completed cases enlisted early from the COVID Symptom Study Smartphone application, yielding six distinct symptom presentations.
Journal ArticleDOI
Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma
Karla A. Lee,Andrew Maltez Thomas,Laura A Bolte,Johannes R. Björk,Laura Kist de Ruijter,Federica Armanini,Francesco Asnicar,Aitor Blanco-Míguez,Ruth Board,Neus Calbet-Llopart,Lisa Derosa,Nathalie Dhomen,Kelly Brooks,Mark Harland,Mark Harries,Emily R Leeming,Paul Lorigan,Paolo Manghi,Richard Marais,Julia Newton-Bishop,Luigi Nezi,Federica Pinto,Miriam Potrony,Susana Puig,Patricio Serra-Bellver,Heather Shaw,Sabrina Tamburini,Sara Valpione,Amrita Vijay,Levi Waldron,Laurence Zitvogel,Moreno Zolfo,Elisabeth G.E. de Vries,Paul Nathan,Rudolf S N Fehrmann,Veronique Bataille,Geke A. P. Hospers,Tim D. Spector,Rinse K. Weersma,Nicola Segata +39 more
TL;DR: The role of the human gut microbiome in immune checkpoint inhibitor (ICI) response appears more complex than previously thought, extending beyond differing microbial species simply present or absent in responders and nonresponders as discussed by the authors .