K
Kassandra M. Ori-McKenney
Researcher at University of California, Davis
Publications - 38
Citations - 2383
Kassandra M. Ori-McKenney is an academic researcher from University of California, Davis. The author has contributed to research in topics: Microtubule & Dynein. The author has an hindex of 15, co-authored 30 publications receiving 1723 citations. Previous affiliations of Kassandra M. Ori-McKenney include University of Minnesota & University of California, San Francisco.
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Journal ArticleDOI
Psychedelics Promote Structural and Functional Neural Plasticity
Calvin Ly,Alexandra C. Greb,Lindsay P. Cameron,Jonathan M. Wong,Eden V. Barragan,Paige C. Wilson,Kyle F. Burbach,Sina Soltanzadeh Zarandi,Alexander Sood,Michael R. Paddy,Whitney C. Duim,Megan Y. Dennis,A. Kimberley McAllister,Kassandra M. Ori-McKenney,John A. Gray,David E. Olson +15 more
TL;DR: It is reported that, like ketamine, serotonergic psychedelics are capable of robustly increasing neuritogenesis and/or spinogenesis both in vitro and in vivo.
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Golgi Outposts Shape Dendrite Morphology by Functioning as Sites of Acentrosomal Microtubule Nucleation in Neurons
TL;DR: Using a combination of in vivo and in vitro techniques, this work finds that Golgi outposts can directly nucleate microtubules throughout the arbor of class IV da neurons, and identifies a direct mechanism for acentrosomal microtubule nucleation within neurons.
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Mutations in the tail domain of DYNC1H1 cause dominant spinal muscular atrophy
Matthew B. Harms,Kassandra M. Ori-McKenney,Mariacristina Scoto,E.P. Tuck,Shaughn Bell,Duanduan Ma,S. Masi,Peggy Allred,M. Al-Lozi,Mary M. Reilly,Lindsey J. Miller,Agnes Jani-Acsadi,Alan Pestronk,Michael E. Shy,Francesco Muntoni,Richard B. Vallee,Robert H. Baloh +16 more
TL;DR: It is demonstrated that mutations in the tail domain of the heavy chain of cytoplasmic dynein (DYNC1H1) cause spinal muscular atrophy and provided experimental evidence that a human DYNC 1H1 mutation disrupts dyne in complex assembly and function.
Journal ArticleDOI
Multiple modes of cytoplasmic dynein regulation
Richard B. Vallee,Richard J. McKenney,Richard J. McKenney,Kassandra M. Ori-McKenney,Kassandra M. Ori-McKenney +4 more
TL;DR: In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dyneIn complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity.
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A cytoplasmic dynein tail mutation impairs motor processivity
TL;DR: Using biochemical, single-molecule, and live-cell-imaging techniques, a marked inhibition of motor run-length in vitro and in vivo, and significantly altered motor domain coordination in the dynein from mutant mice are found.