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Megan Y. Dennis
Researcher at MIND Institute
Publications - 41
Citations - 4179
Megan Y. Dennis is an academic researcher from MIND Institute. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 19, co-authored 33 publications receiving 3225 citations. Previous affiliations of Megan Y. Dennis include Wellcome Trust Centre for Human Genetics & Michigan State University.
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Journal ArticleDOI
Resolving the complexity of the human genome using single-molecule sequencing
Mark Chaisson,John Huddleston,Megan Y. Dennis,Peter H. Sudmant,Maika Malig,Fereydoun Hormozdiari,Francesca Antonacci,Urvashi Surti,Richard Sandstrom,Matthew Boitano,Jane M. Landolin,John A. Stamatoyannopoulos,Michael W. Hunkapiller,Jonas Korlach,Evan E. Eichler +14 more
TL;DR: A greater complexity of the human genome in the form of variation of longer and more complex repetitive DNA that can now be largely resolved with the application of this longer-read sequencing technology is suggested.
Journal ArticleDOI
Telomere-to-telomere assembly of a complete human X chromosome
Karen H. Miga,Sergey Koren,Arang Rhie,Mitchell R. Vollger,Ariel Gershman,Andrey Bzikadze,Shelise Brooks,Edmund Howe,David Porubsky,Glennis A. Logsdon,Valerie A. Schneider,Tamara A. Potapova,Jonathan Wood,William Chow,Joel Armstrong,Jeanne Fredrickson,Evgenia Pak,Kristof Tigyi,Milinn Kremitzki,Christopher Markovic,Valerie Maduro,Amalia Dutra,Gerard G. Bouffard,Alexander M. Chang,Nancy F. Hansen,Amy B. Wilfert,Françoise Thibaud-Nissen,Anthony D. Schmitt,Jon Matthew Belton,Siddarth Selvaraj,Megan Y. Dennis,Daniela C. Soto,Ruta Sahasrabudhe,Gulhan Kaya,Josh Quick,Nicholas J. Loman,Nadine Holmes,Matthew Loose,Urvashi Surti,Rosa Ana Risques,Tina A. Graves Lindsay,Robert S. Fulton,Ira M. Hall,Benedict Paten,Kerstin Howe,Winston Timp,Alice Young,James C. Mullikin,Pavel A. Pevzner,Jennifer L. Gerton,Beth A. Sullivan,Evan E. Eichler,Adam M. Phillippy +52 more
TL;DR: High-coverage, ultra-long-read nanopore sequencing is used to create a new human genome assembly that improves on the coverage and accuracy of the current reference (GRCh38) and includes the gap-free, telomere-to-telomere sequence of the X chromosome.
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Psychedelics Promote Structural and Functional Neural Plasticity
Calvin Ly,Alexandra C. Greb,Lindsay P. Cameron,Jonathan M. Wong,Eden V. Barragan,Paige C. Wilson,Kyle F. Burbach,Sina Soltanzadeh Zarandi,Alexander Sood,Michael R. Paddy,Whitney C. Duim,Megan Y. Dennis,A. Kimberley McAllister,Kassandra M. Ori-McKenney,John A. Gray,David E. Olson +15 more
TL;DR: It is reported that, like ketamine, serotonergic psychedelics are capable of robustly increasing neuritogenesis and/or spinogenesis both in vitro and in vivo.
Journal ArticleDOI
Evolution of Human-Specific Neural SRGAP2 Genes by Incomplete Segmental Duplication
Megan Y. Dennis,Xander Nuttle,Peter H. Sudmant,Francesca Antonacci,Tina Graves,Mikhail Nefedov,Jill A. Rosenfeld,Saba Sajjadian,Maika Malig,Holland Kotkiewicz,Cynthia J. Curry,Susan Shafer,Lisa G. Shaffer,Pieter J. de Jong,Richard K. Wilson,Evan E. Eichler +15 more
TL;DR: The data suggest a mechanism where incomplete duplication created a novel gene function-antagonizing parental SRGAP2 function-immediately "at birth" 2-3 mya, which is a time corresponding to the transition from Australopithecus to Homo and the beginning of neocortex expansion.
Journal ArticleDOI
Refinement and Discovery of New Hotspots of Copy-Number Variation Associated with Autism Spectrum Disorder
Santhosh Girirajan,Megan Y. Dennis,Carl Baker,Maika Malig,Bradley P. Coe,Catarina D. Campbell,Kenneth M. K. Mark,Tiffany H. Vu,Can Alkan,Ze Cheng,Leslie G. Biesecker,Raphael Bernier,Evan E. Eichler +12 more
TL;DR: The absence of an increased burden of smaller CNVs in individuals with autism and the failure of most large hotspots to refine to single genes is consistent with a model where imbalance of multiple genes contributes to a disease state.