K
Katherine Baran
Researcher at St. Jude Children's Research Hospital
Publications - 15
Citations - 1644
Katherine Baran is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Granzyme & Perforin. The author has an hindex of 11, co-authored 15 publications receiving 1502 citations. Previous affiliations of Katherine Baran include Children's Medical Research Institute & Garvan Institute of Medical Research.
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Journal ArticleDOI
The structural basis for membrane binding and pore formation by lymphocyte perforin
Ruby H. P. Law,Natalya Lukoyanova,Ilia Voskoboinik,Ilia Voskoboinik,Tom T. Caradoc-Davies,Katherine Baran,Michelle A. Dunstone,Michelle A. Dunstone,Michael E. D'Angelo,Elena V. Orlova,Fasséli Coulibaly,Sandra Verschoor,Kylie A. Browne,Annette Ciccone,Michael J. Kuiper,Phillip I. Bird,Joseph A. Trapani,Joseph A. Trapani,Helen R. Saibil,James C. Whisstock,James C. Whisstock +20 more
TL;DR: In this article, the X-ray crystal structure of perforin pore formation was determined using a cryo-electron microscopy reconstruction, which revealed remarkable flexibility in the mechanism of action and provided new insights into how related immune defence molecules such as complement proteins assemble into pores.
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A Common Fold Mediates Vertebrate Defense and Bacterial Attack
Carlos J. Rosado,Ashley M. Buckle,Ruby H. P. Law,Rebecca Elizabeth Butcher,Rebecca Elizabeth Butcher,Wan-Ting Kan,Wan-Ting Kan,Catherina H. Bird,Kheng Sok Ung,Kylie A. Browne,Katherine Baran,Tanya Ann Bashtannyk-Puhalovich,Noel G. Faux,Wilson Wong,Wilson Wong,Corrine Joy Porter,Corrine Joy Porter,Robert N. Pike,Andrew M. Ellisdon,Mary Catherine Pearce,Stephen P. Bottomley,Jonas Emsley,A. Ian Smith,A. Ian Smith,Jamie Rossjohn,Jamie Rossjohn,Elizabeth L. Hartland,Ilia Voskoboinik,Ilia Voskoboinik,Joseph A. Trapani,Joseph A. Trapani,Phillip I. Bird,Michelle A. Dunstone,James C. Whisstock,James C. Whisstock +34 more
TL;DR: Sequence similarity between bacterial and vertebrate MACPF domains suggests that the fold of the CDCs, a family of proteins important for bacterial pathogenesis, is probably used by vertebrates for defense against infection.
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Human POT1 facilitates telomere elongation by telomerase.
TL;DR: It is shown that human POT1 can act as a telomerase-dependent, positive regulator of telomere length and that a normal function of hPOT1 is to facilitate telomeres elongation by telomersase.
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Perforin: structure, function, and role in human immunopathology
Ilia Voskoboinik,Michelle A. Dunstone,Katherine Baran,James C. Whisstock,Joseph A. Trapani,Joseph A. Trapani +5 more
TL;DR: This review discusses the current state of affairs in the perforin field: the protein’s structure and function as well as its role in immune‐mediated diseases.
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PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis
Ariele Viacava Follis,Jerry E. Chipuk,Jerry E. Chipuk,John C Fisher,John C Fisher,Mi-Kyung Yun,Christy R. Grace,Amanda Nourse,Katherine Baran,Li Ou,Lie Min,Stephen W. White,Stephen W. White,Douglas R. Green,Richard W. Kriwacki,Richard W. Kriwacki +15 more
TL;DR: It is proposed that regulated unfolding of BCL-xL provides a mechanism to promote PUMA-dependent signaling within the apoptotic pathways, and p53-dependent, DNA damage-induced apoptosis is promoted.