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A. Ian Smith
Researcher at Monash University
Publications - 139
Citations - 7231
A. Ian Smith is an academic researcher from Monash University. The author has contributed to research in topics: Venom & Antivenom. The author has an hindex of 39, co-authored 139 publications receiving 6138 citations. Previous affiliations of A. Ian Smith include Monash University, Clayton campus & Monash Institute of Medical Research.
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Journal ArticleDOI
Tumor necrosis factor-α convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
Daniel W. Lambert,Mike Yarski,Fiona J. Warner,Paul Thornhill,Edward T. Parkin,A. Ian Smith,Nigel M. Hooper,Anthony J. Turner +7 more
TL;DR: Direct evidence is provided for the involvement of ADAM17 in the regulated ectodomain shedding of ACE2 by using inhibitors with differing potency toward different members of the ADAM (a disintegrin and metalloproteinase) family of proteases.
Journal ArticleDOI
Proopiomelanocortin Processing in the Pituitary, Central Nervous System, and Peripheral Tissues
A. Ian Smith,John W. Funder +1 more
TL;DR: To yield biologically active products, precursors commonly undergo a series of highly organized posttranslational events, including selective proteolytic cleavage and other enzymatic modifications which take place within specific membrane-bounded compartments.
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Myocardial infarction increases ACE2 expression in rat and humans.
Louise M Burrell,John Risvanis,Eiji Kubota,Rachael G Dean,Peter S. Macdonald,Sai Lu,Christos Tikellis,Sharon L. Grant,Rebecca A. Lew,A. Ian Smith,Mark E. Cooper,Colin I. Johnston +11 more
TL;DR: The increase in ACE2 after MI suggests that it plays an important role in the negative modulation of the renin angiotensin system in the generation and degradation of angiotENSin peptides after cardiac injury.
Journal ArticleDOI
iFeature: a Python package and web server for features extraction and selection from protein and peptide sequences.
Zhen Chen,Pei Zhao,Fuyi Li,André Leier,Tatiana T. Marquez-Lago,Yanan Wang,Geoffrey I. Webb,A. Ian Smith,Roger J. Daly,Kuo-Chen Chou,Jiangning Song +10 more
TL;DR: iFeature is a versatile Python‐based toolkit for generating various numerical feature representation schemes for both protein and peptide sequences, capable of calculating and extracting a comprehensive spectrum of 18 major sequence encoding schemes that encompass 53 different types of feature descriptors.
Journal ArticleDOI
A Common Fold Mediates Vertebrate Defense and Bacterial Attack
Carlos J. Rosado,Ashley M. Buckle,Ruby H. P. Law,Rebecca Elizabeth Butcher,Rebecca Elizabeth Butcher,Wan-Ting Kan,Wan-Ting Kan,Catherina H. Bird,Kheng Sok Ung,Kylie A. Browne,Katherine Baran,Tanya Ann Bashtannyk-Puhalovich,Noel G. Faux,Wilson Wong,Wilson Wong,Corrine Joy Porter,Corrine Joy Porter,Robert N. Pike,Andrew M. Ellisdon,Mary Catherine Pearce,Stephen P. Bottomley,Jonas Emsley,A. Ian Smith,A. Ian Smith,Jamie Rossjohn,Jamie Rossjohn,Elizabeth L. Hartland,Ilia Voskoboinik,Ilia Voskoboinik,Joseph A. Trapani,Joseph A. Trapani,Phillip I. Bird,Michelle A. Dunstone,James C. Whisstock,James C. Whisstock +34 more
TL;DR: Sequence similarity between bacterial and vertebrate MACPF domains suggests that the fold of the CDCs, a family of proteins important for bacterial pathogenesis, is probably used by vertebrates for defense against infection.