M
Martin R. Jakobsen
Researcher at Aarhus University
Publications - 91
Citations - 4786
Martin R. Jakobsen is an academic researcher from Aarhus University. The author has contributed to research in topics: Innate immune system & Sting. The author has an hindex of 31, co-authored 80 publications receiving 3446 citations. Previous affiliations of Martin R. Jakobsen include Cornell University & Monash University.
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Journal ArticleDOI
Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage.
Gillian Dunphy,Sinead M. Flannery,Jessica F. Almine,Dympna J. Connolly,Christina Paulus,Kasper L Jønsson,Martin R. Jakobsen,Michael Nevels,Andrew G. Bowie,Leonie Unterholzner +9 more
TL;DR: It is found that keratinocytes and other human cells mount an innate immune response within hours of etoposide-induced DNA damage, which involves the DNA sensing adaptor STING but is independent of the cytosolic DNA receptor cGAS.
Journal ArticleDOI
Low-frequency HIV-1 drug resistance mutations and risk of NNRTI-based antiretroviral treatment failure: a systematic review and pooled analysis
Jonathan Z. Li,Roger Paredes,Heather J. Ribaudo,Evguenia S. Svarovskaia,Karin J. Metzner,Michael J. Kozal,Katherine Huppler Hullsiek,Melanie Balduin,Martin R. Jakobsen,Anna Maria Geretti,Rodolphe Thiébaut,Lars Østergaard,Bernard Masquelier,Jeffrey A. Johnson,Michael D. Miller,Daniel R. Kuritzkes +15 more
TL;DR: In a pooled analysis, low-frequency HIV-1 drug resistance mutations, particularly involving NNRTI resistance, were significantly associated with a dose-dependent increased risk of virologic failure with first-line ART.
Journal ArticleDOI
IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
Martin R. Jakobsen,Rasmus O. Bak,Annika Andersen,Randi K. Berg,Randi K. Berg,Søren B. Jensen,Tengchuan Jin,Anders Laustsen,Kathrine Hansen,Lars Østergaard,Katherine A. Fitzgerald,T. Sam Xiao,Jacob Giehm Mikkelsen,Trine H. Mogensen,Søren R. Paludan +14 more
TL;DR: IFI16 is a sensor for DNA forms produced during the lentiviral replication cycle and regulates HIV-1 replication in macrophages, which contribute to early control of the virus.
Journal ArticleDOI
Attenuation of cGAS-STING Signaling Is Mediated by a p62/SQSTM1-dependent Autophagy Pathway Activated by TBK1
Thaneas Prabakaran,Chiranjeevi Bodda,Chiranjeevi Bodda,Christian Krapp,Bao-Cun Zhang,Maria H Christensen,Chenglong Sun,Line S. Reinert,Yujia Cai,Søren B. Jensen,Morten K Skouboe,Jens R. Nyengaard,Craig B. Thompson,Robert Jan Lebbink,Ganes C. Sen,Geert van Loo,Rikke Nielsen,Masaaki Komatsu,Lene N. Nejsum,Martin R. Jakobsen,Mads Gyrd-Hansen,Søren R. Paludan +21 more
TL;DR: It is reported that STING degradation following activation of the pathway occurs through autophagy and is mediated by p62/SQSTM1, which is phosphorylated by TBK1 to direct ubiquitinated STING to autophagosomes.
Journal ArticleDOI
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
David Olagnier,Ensieh Farahani,Jacob Thyrsted,Julia Blay-Cadanet,Angela Herengt,Manja Idorn,Alon Schneider Hait,Alon Schneider Hait,Bruno Hernáez,Alice Knudsen,Marie B. Iversen,Mirjam Schilling,Sofie E. Jørgensen,Sofie E. Jørgensen,Michelle M. Thomsen,Michelle M. Thomsen,Line S. Reinert,Michael Lappe,Huy-Dung Hoang,Victoria H. Gilchrist,Anne Louise Hansen,Rasmus Ottosen,Camilla G. Nielsen,Charlotte Möller,Demi van der Horst,Suraj Peri,Siddharth Balachandran,Jinrong Huang,Martin R. Jakobsen,Esben B. Svenningsen,Thomas B. Poulsen,Lydia Bartsch,Anne L. Thielke,Yonglun Luo,Tommy Alain,Jan Rehwinkel,Antonio Alcami,John Hiscott,Trine H. Mogensen,Trine H. Mogensen,Søren R. Paludan,Christian K. Holm +41 more
TL;DR: NRF2 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication and in suppressing the pro-inflammatory responses of human pathogenic viruses, including SARS-CoV2.