K
Kathleen D. Eisenach
Researcher at University of Arkansas for Medical Sciences
Publications - 94
Citations - 6665
Kathleen D. Eisenach is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 44, co-authored 93 publications receiving 6254 citations. Previous affiliations of Kathleen D. Eisenach include University of Arkansas at Little Rock & Case Western Reserve University.
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Journal ArticleDOI
Polymerase Chain Reaction Amplification of a Repetitive DNA Sequence Specific for Mycobacterium tuberculosis
TL;DR: A segment of DNA repeated in the chromosome of Mycobacterium tuberculosis was sequenced and used as a target for amplification using polymerase chain reaction (PCR) and may provide the basis for an assay to detect M. tuberculosis directly in clinical material.
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Global Phylogeny of Mycobacterium tuberculosis Based on Single Nucleotide Polymorphism (SNP) Analysis: Insights into Tuberculosis Evolution, Phylogenetic Accuracy of Other DNA Fingerprinting Systems, and Recommendations for a Minimal Standard SNP Set
Ingrid Filliol,Alifiya S. Motiwala,Magali Cavatore,Weihong Qi,Manzour Hernando Hazbón,Miriam Bobadilla-del Valle,Janet A. M. Fyfe,Lourdes García-García,Nalin Rastogi,Christophe Sola,TThierry Zozio,Marta Inírida Guerrero,Clara Inés León,Jonathan Crabtree,Samuel V. Angiuoli,Kathleen D. Eisenach,Riza Durmaz,Moses Joloba,Adrian Rendon,José Sifuentes-Osornio,Alfredo Ponce de León,M. Donald Cave,Robert D. Fleischmann,Thomas S. Whittam,David Alland +24 more
TL;DR: A global collection of Mycobacterium tuberculosis strains using 212 single nucleotide polymorphism (SNP) markers was analyzed to enable global collaborations for studies on evolution, strain differentiation, and biological differences of M. tuberculosis.
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Population Genetics Study of Isoniazid Resistance Mutations and Evolution of Multidrug-Resistant Mycobacterium tuberculosis
Manzour Hernando Hazbón,Michael Brimacombe,Miriam Bobadilla-del Valle,Magali Cavatore,Marta Inírida Guerrero,Mandira Varma-Basil,Helen Billman-Jacobe,Caroline J. Lavender,Janet A. M. Fyfe,Lourdes García-García,Clara Inés León,Mridula Bose,Fernando Chaves,Megan Murray,Kathleen D. Eisenach,José Sifuentes-Osornio,M. Donald Cave,Alfredo Ponce de León,David Alland +18 more
TL;DR: The results suggest that isoniazid resistance and the evolution of multidrug-resistant strains are complex dynamic processes that may be influenced by interactions between genes and drug-resistant phenotypes.
Journal ArticleDOI
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.
David Stucki,David Stucki,Daniela Brites,Daniela Brites,Leïla Jeljeli,Mireia Coscolla,Mireia Coscolla,Qingyun Liu,Andrej Trauner,Andrej Trauner,Lukas Fenner,Lukas Fenner,Lukas Fenner,Liliana K. Rutaihwa,Liliana K. Rutaihwa,Sonia Borrell,Sonia Borrell,Tao Luo,Qian Gao,Midori Kato-Maeda,Marie Ballif,Marie Ballif,Marie Ballif,Matthias Egger,Rita Macedo,Helmi Mardassi,Milagros Moreno,Griselda Tudo Vilanova,Janet A. M. Fyfe,Maria Globan,Jackson Thomas,Frances B. Jamieson,Jennifer L. Guthrie,Adwoa Asante-Poku,Dorothy Yeboah-Manu,Eddie M. Wampande,Willy Ssengooba,Willy Ssengooba,Moses Joloba,W. Henry Boom,Indira Basu,James E. Bower,Margarida Saraiva,Sidra Ezidio Gonçalves Vasconcellos,Philip Noel Suffys,Anastasia Koch,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Linda Gail-Bekker,Bijaya Malla,Bijaya Malla,Serej D. Ley,Serej D. Ley,Serej D. Ley,Hans-Peter Beck,Hans-Peter Beck,Bouke C. de Jong,Kadri Toit,Elisabeth Sanchez-Padilla,Maryline Bonnet,Ana Gil-Brusola,Matthias Frank,Véronique Penlap Beng,Kathleen D. Eisenach,Issam Alani,Perpetual Wangui Ndung'u,Gunturu Revathi,Florian Gehre,Florian Gehre,Suriya Akter,Francine Ntoumi,Lynsey Stewart-Isherwood,Nyanda E. Ntinginya,Andrea Rachow,Michael Hoelscher,Daniela Maria Cirillo,Girts Skenders,Sven Hoffner,Daiva Bakonyte,Petras Stakenas,Roland Diel,Valeriu Crudu,Olga Domnica Moldovan,Sahal Al-Hajoj,Larissa Otero,Francesca Barletta,E. Jane Carter,E. Jane Carter,Lameck Diero,Philip Supply,Iñaki Comas,Stefan Niemann,Sebastien Gagneux,Sebastien Gagneux +94 more
TL;DR: It is shown that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists, and further support a European origin for the most common generalist sublineage.
Journal ArticleDOI
IS6110: conservation of sequence in the Mycobacterium tuberculosis complex and its utilization in DNA fingerprinting.
M. Donald Cave,Kathleen D. Eisenach,Patrick F. McDermott,Joseph H. Bates,Joseph H. Bates,Jack T. Crawford,Jack T. Crawford +6 more
TL;DR: Multiple copies of an insertion sequence, IS6110, were shown to be present in the genome of members of the Mycobacterium tuberculosis complex (M. tuberculosis and M. bovis).