H
Hans-Peter Beck
Researcher at University of Basel
Publications - 176
Citations - 11171
Hans-Peter Beck is an academic researcher from University of Basel. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 59, co-authored 175 publications receiving 10360 citations. Previous affiliations of Hans-Peter Beck include Swiss Tropical and Public Health Institute & Walter and Eliza Hall Institute of Medical Research.
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Journal ArticleDOI
Spiroindolones, a Potent Compound Class for the Treatment of Malaria
Matthias Rottmann,Matthias Rottmann,Case W. McNamara,Bryan K. S. Yeung,Marcus C. S. Lee,Bin Zou,Bruce Russell,Bruce Russell,Patrick Seitz,Patrick Seitz,David Plouffe,Neekesh V. Dharia,Jocelyn Tan,Steven Cohen,Kathryn S. R. Spencer,Gonzalo E. González-Páez,Suresh B. Lakshminarayana,Anne Goh,Rossarin Suwanarusk,Timothy Jegla,Esther K. Schmitt,Hans-Peter Beck,Hans-Peter Beck,Reto Brun,Reto Brun,François Nosten,François Nosten,Laurent Rénia,Véronique Dartois,Thomas H. Keller,David A. Fidock,Elizabeth A. Winzeler,Elizabeth A. Winzeler,Thierry T. Diagana +33 more
TL;DR: The preclinical profile for an optimized spiroindolone drug candidate, NITD609, shows pharmacokinetic properties compatible with once-daily oral dosing and has single-dose efficacy in a rodent malaria model.
Journal ArticleDOI
A recombinant blood-stage malaria vaccine reduces Plasmodium falciparum density and exerts selective pressure on parasite populations in a phase 1-2b trial in Papua New Guinea.
B. Genton,Inoni Betuela,Ingrid Felger,F. Al-Yaman,Robin F. Anders,Robin F. Anders,Allan James Saul,Allan James Saul,Lawrence Rare,Moses Baisor,Kerry Lorry,Graham Brown,David Pye,David O. Irving,Thomas J. Smith,Hans-Peter Beck,Michael P. Alpers +16 more
TL;DR: Functional activity of Combination B against P. falciparum is demonstrated in individuals with previous malaria exposure and the specific effects on parasites with particular msp2 genotypes suggest that the MSP2 component, at least in part, accounted for the activity.
Journal ArticleDOI
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.
David Stucki,David Stucki,Daniela Brites,Daniela Brites,Leïla Jeljeli,Mireia Coscolla,Mireia Coscolla,Qingyun Liu,Andrej Trauner,Andrej Trauner,Lukas Fenner,Lukas Fenner,Lukas Fenner,Liliana K. Rutaihwa,Liliana K. Rutaihwa,Sonia Borrell,Sonia Borrell,Tao Luo,Qian Gao,Midori Kato-Maeda,Marie Ballif,Marie Ballif,Marie Ballif,Matthias Egger,Rita Macedo,Helmi Mardassi,Milagros Moreno,Griselda Tudo Vilanova,Janet A. M. Fyfe,Maria Globan,Jackson Thomas,Frances B. Jamieson,Jennifer L. Guthrie,Adwoa Asante-Poku,Dorothy Yeboah-Manu,Eddie M. Wampande,Willy Ssengooba,Willy Ssengooba,Moses Joloba,W. Henry Boom,Indira Basu,James E. Bower,Margarida Saraiva,Sidra Ezidio Gonçalves Vasconcellos,Philip Noel Suffys,Anastasia Koch,Robert J. Wilkinson,Robert J. Wilkinson,Robert J. Wilkinson,Linda Gail-Bekker,Bijaya Malla,Bijaya Malla,Serej D. Ley,Serej D. Ley,Serej D. Ley,Hans-Peter Beck,Hans-Peter Beck,Bouke C. de Jong,Kadri Toit,Elisabeth Sanchez-Padilla,Maryline Bonnet,Ana Gil-Brusola,Matthias Frank,Véronique Penlap Beng,Kathleen D. Eisenach,Issam Alani,Perpetual Wangui Ndung'u,Gunturu Revathi,Florian Gehre,Florian Gehre,Suriya Akter,Francine Ntoumi,Lynsey Stewart-Isherwood,Nyanda E. Ntinginya,Andrea Rachow,Michael Hoelscher,Daniela Maria Cirillo,Girts Skenders,Sven Hoffner,Daiva Bakonyte,Petras Stakenas,Roland Diel,Valeriu Crudu,Olga Domnica Moldovan,Sahal Al-Hajoj,Larissa Otero,Francesca Barletta,E. Jane Carter,E. Jane Carter,Lameck Diero,Philip Supply,Iñaki Comas,Stefan Niemann,Sebastien Gagneux,Sebastien Gagneux +94 more
TL;DR: It is shown that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists, and further support a European origin for the most common generalist sublineage.
Journal ArticleDOI
Identification and Differentiation of Leishmania Species in Clinical Samples by PCR Amplification of the Miniexon Sequence and Subsequent Restriction Fragment Length Polymorphism Analysis
Jutta Marfurt,Abed Nasereddin,Igor Niederwieser,Charles L. Jaffe,Hans-Peter Beck,Ingrid Felger +5 more
TL;DR: The miniexon PCR-RFLP assay provides a valuable tool for the identification of Leishmania directly from clinical samples and enables determination of the infecting species by a facile technique with high discrimination power and might improve diagnosis and treatment of leishmaniasis.
Journal ArticleDOI
11. Premunition in Plasmodium falciparum infection: insights from the epidemiology of multiple infections
TL;DR: In this paper, the authors hypothesize that, in infants, host defence against blood-stage infections with Plasmodium falciparum relies mainly on fever and cytokine activities, and the infections are of short duration.