K
Katrina J. Ashworth
Researcher at Washington University in St. Louis
Publications - 18
Citations - 511
Katrina J. Ashworth is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Platelet & Von Willebrand factor. The author has an hindex of 6, co-authored 11 publications receiving 335 citations. Previous affiliations of Katrina J. Ashworth include Monash University & Anschutz Medical Campus.
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Journal ArticleDOI
TNF-α–driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging
Pavel Davizon-Castillo,Brandon McMahon,Sonia Aguila,David Bark,Katrina J. Ashworth,Ayed Allawzi,Robert A. Campbell,Emilie Montenont,Travis Nemkov,Angelo D'Alessandro,Nathan Clendenen,Lauren Shih,Natalie A. Sanders,Natalie A. Sanders,Kelly Higa,Allaura Cox,Zavelia Padilla-Romo,Giovanni Hernandez,Eric P. Wartchow,George Devon Trahan,Eva Nozik-Grayck,Kenneth L. Jones,Eric M. Pietras,James DeGregori,Matthew T. Rondina,Jorge Di Paola +25 more
TL;DR: Previously-unrecognized evidence is presented that TNF- critically regulates megakaryocytes resident in the bone marrow niche and aging-associated platelet hyperreactivity and thrombosis and age-dependent metabolic profiles that may differentially poise platelets for activation.
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The CXCR1/2 ligand NAP-2 promotes directed intravascular leukocyte migration through platelet thrombi.
Mehran Ghasemzadeh,Zane Kaplan,Imala Alwis,Simone M. Schoenwaelder,Katrina J. Ashworth,Erik Westein,Ehteramolsadat Hosseini,Hatem H. Salem,Robyn Maree Slattery,Shaun R. McColl,Michael J. Hickey,Zaverio M. Ruggeri,Yuping Yuan,Shaun P. Jackson,Shaun P. Jackson +14 more
TL;DR: A distinct process of leukocyte migration is defined that is initiated by homotypic adhesive interactions between platelets, leading to the development of an NAP-2 chemotactic gradient within the thrombus body that guides leukocytes to sites of vascular injury.
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High shear–dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction
Susan L. Cranmer,Katrina J. Ashworth,Yu Yao,Michael C. Berndt,Zaverio M. Ruggeri,Robert K. Andrews,Shaun P. Jackson +6 more
TL;DR: These outcomes suggest that the GPIbα-filamin A interaction not only regulates the architecture of the membrane skeleton, but also maintains the mechanical stability of the plasma membrane under conditions of high shear.
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Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia
Yuping Yuan,Yuping Yuan,Yuping Yuan,Imala Alwis,Imala Alwis,Imala Alwis,Mike C. L. Wu,Mike C. L. Wu,Mike C. L. Wu,Zane Kaplan,Katrina J. Ashworth,David Bark,Alan Pham,James D. McFadyen,Simone M. Schoenwaelder,Simone M. Schoenwaelder,Emma C. Josefsson,Emma C. Josefsson,Benjamin T. Kile,Benjamin T. Kile,Benjamin T. Kile,Shaun P. Jackson +21 more
TL;DR: It is demonstrated that gut ischemia in the mouse induces a distinct pulmonary thrombotic disorder triggered by neutrophil macroaggregates, which leads to widespread occlusion of pulmonary arteries, veins, and the microvasculature in humans with the acute respiratory distress syndrome.
Journal ArticleDOI
Turbulent Flow Promotes Cleavage of VWF (von Willebrand Factor) by ADAMTS13 (A Disintegrin and Metalloproteinase With a Thrombospondin Type-1 Motif, Member 13).
Maria Bortot,Katrina J. Ashworth,Alireza Sharifi,Faye Walker,Nathan Crawford,Keith B. Neeves,David Bark,David Bark,Jorge Di Paola +8 more
TL;DR: Turbulent flow mediates VWF cleavage in the presence of ADAMTS13, decreasing the ability of VWF to sustain platelet adhesion and affecting the design of mechanical circulatory support devices where turbulence is added to circulation.