K
Kazuishi Kubota
Researcher at Daiichi Sankyo
Publications - 46
Citations - 2295
Kazuishi Kubota is an academic researcher from Daiichi Sankyo. The author has contributed to research in topics: Phosphorylation & Kinase. The author has an hindex of 21, co-authored 44 publications receiving 2078 citations. Previous affiliations of Kazuishi Kubota include Harvard University & University of Tokyo.
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Journal ArticleDOI
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex.
Shingo Kajimura,Patrick Seale,Kazuishi Kubota,Elaine P. Lunsford,John V. Frangioni,Steven P. Gygi,Bruce M. Spiegelman +6 more
TL;DR: It is shown that PRDM16 forms a transcriptional complex with the active form of C/EBP-β (also known as LAP), acting as a critical molecular unit that controls the cell fate switch from myoblastic precursors to brown fat cells.
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Regulation of meiotic recombination via Mek1-mediated Rad54 phosphorylation
Hengyao Niu,Lihong Wan,Valeria Busygina,Youngho Kwon,Jasmina A. Allen,Xue Li,Ryan C. Kunz,Kazuishi Kubota,Beatrice Wang,Patrick Sung,Kevan M. Shokat,Steven P. Gygi,Nancy M. Hollingsworth +12 more
TL;DR: Mek1 phosphorylation provides a dynamic means of controlling recombination partner choice in meiosis in two ways: (1) it reduces Rad51 activity through inhibition of Rad51/Rad54 complex formation, and (2) it suppresses Rad51-mediated strand invasion of sister chromatids via a Rad54-independent mechanism.
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Open sandwich ELISA: a novel immunoassay based on the interchain interaction of antibody variable region
Hiroshi Ueda,Kouhei Tsumoto,Kazuishi Kubota,Eiji Suzuki,Teruyuki Nagamune,Hajime Nishimura,Paula A. Schueler,Greg Winter,Izumi Kumagai,Walter C. Mahoney +9 more
TL;DR: An immunoassay that is based on the interchain interaction of separated VL and VH chains from a single chain antibody variable region that detects signal in direct proportion to the amount of HEL in the sample is described.
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Platelet-derived growth factor BB secreted from osteoclasts acts as an osteoblastogenesis inhibitory factor.
TL;DR: Results show, for the first time, that osteoclasts regulate osteoblasts directly and suggest that PDGF BB is a key factor in bone remodeling.
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Comparison of enzymatic properties between hPADI2 and hPADI4.
Makiko Nakayama-Hamada,Akari Suzuki,Kazuishi Kubota,Tomoko Takazawa,Mizuko Ohsaka,Reimi Kawaida,Mitsuru Ono,Atsushi Kasuya,Hidehiko Furukawa,Ryo Yamada,Kazuhiko Yamamoto +10 more
TL;DR: To understand the mechanisms of the initiation and progression of RA, the properties of two PADIs, human P ADI2 and human PADI4, which are present in the synovial tissues of RA patients are compared and it is indicated that hPADI 2 and hP ADI4 have different roles under physiological and pathological conditions.