K
Keefe B. Manning
Researcher at Pennsylvania State University
Publications - 120
Citations - 2301
Keefe B. Manning is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Pulsatile flow & Particle image velocimetry. The author has an hindex of 22, co-authored 108 publications receiving 1888 citations. Previous affiliations of Keefe B. Manning include Virginia Commonwealth University & Penn State Milton S. Hershey Medical Center.
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Journal ArticleDOI
Tri-layered elastomeric scaffolds for engineering heart valve leaflets
Nafiseh Masoumi,Nasim Annabi,Alexander Assmann,Benjamin L. Larson,Jesper Hjortnaes,Neslihan Alemdar,Mahshid Kharaziha,Keefe B. Manning,John E. Mayer,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini +11 more
TL;DR: The engineered tri-layered scaffolds have the potential for successful translation towards TEHV replacements and opened and closed properly in an ex vivo model of porcine heart valve leaflet tissue replacement.
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Assessment of CFD Performance in Simulations of an Idealized Medical Device: Results of FDA’s First Computational Interlaboratory Study
Sandy F. C. Stewart,Eric G. Paterson,Greg W. Burgreen,Prasanna Hariharan,Matthew Giarra,Varun Reddy,Steven W. Day,Keefe B. Manning,Steven Deutsch,Michael R. Berman,Matthew R. Myers,Richard A. Malinauskas +11 more
TL;DR: In this article, the authors conducted a computational interlaboratory study to determine the suitability and methodology for simulating fluid flow in an idealized medical device, which was a cylindrical nozzle with a conical collector and sudden expansion on either side of a 0.04 m long, 0.004 m diameter throat.
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Multilaboratory Particle Image Velocimetry Analysis of the FDA Benchmark Nozzle Model to Support Validation of Computational Fluid Dynamics Simulations
Prasanna Hariharan,Matthew Giarra,Varun Reddy,Steven W. Day,Keefe B. Manning,Steven Deutsch,Sandy F. C. Stewart,Matthew R. Myers,Michael R. Berman,Greg W. Burgreen,Eric G. Paterson,Richard A. Malinauskas +11 more
TL;DR: In this paper, the authors evaluate the use and limitations of computational fluid dynamics (CFD) in assessing blood flow parameters related to medical device safety, including mean velocity and turbulent flow quantities.
Journal ArticleDOI
Experimental fluid mechanics of pulsatile artificial blood pumps
TL;DR: The fluid mechanics of artificial blood pumps has been studied since the early 1970s in an attempt to understand and mitigate hemolysis and thrombus formation by the device.
Journal ArticleDOI
FDA Benchmark Medical Device Flow Models for CFD Validation.
Richard A. Malinauskas,Prasanna Hariharan,Steven W. Day,Luke H. Herbertson,Martin Buesen,Ulrich Steinseifer,Kenneth I. Aycock,Bryan C. Good,Steven Deutsch,Keefe B. Manning,Brent A. Craven +10 more
TL;DR: The primary goal of this article is to summarize the FDA initiative and to report recent findings from the benchmark blood pump model study, which aided the development of an FDA Guidance Document on factors to consider when reporting computational studies in medical device regulatory submissions.