Showing papers by "Keiko Shiratori published in 1992"
TL;DR: The results of this study indicate that endogenous secretin rather than CCK is involved in the hormonal mechanism regulating the inhibition of gastric acid secretion by intestinal fat in rats.
Abstract: We investigated a possible role of endogenous secretin and cholecystokinin (CCK) in inhibition of gastric acid secretion induced by intraduodenal administration of oleic acid in rats. Intraduodenal administration of oleic acid emulsion in a dose of 1 mmol/hr resulted in significant inhibition of gastric acid secretion stimulated by intravenous infusion of pentagastrin (0.3 μg/kg/hr), and this was accompanied by an increase in the plasma concentration of both secretin and CCK, from 1.2±0.08 pM and 20.6±1.2 pM to 4.3±0.18 pM and 31.6±0.9 pM, respectively (P<0.001). Intravenous infusion of secretin (0.05 CU/kg/hr) inhibited pentagastrin-stimulated gastric acid secretion, but CCK-8 (0.03 μ/kg/hr) failed, although intravenous infusion of secretin, and CCK in those doses produced plasma levels comparable to the levels achieved in response to oleic acid administration. Furthermore, the oleic acid-induced suppression of gastic acid secretion was blocked significantly by intravenous injection of rabbit anti-secretin serum (0.1 ml), but not by intravenous infusion of a CCK-receptor antagonist, CR 1409 (5 mg/kg/hr). Thus, the results of this study indicate that endogenous secretin rather than CCK is involved in the hormonal mechanism regulating the inhibition of gastric acid secretion by intestinal fat in rats.
15 citations
National Cancer Research Institute1, Osaka University2, University of Michigan3, Kyoto University4, Kyushu University5, Keio University6, Nagoya City University7, Nihon University8, Shiga University of Medical Science9, Gunma University10, Hiroshima University11, Nagoya University12, Tohoku University13, Asahikawa Medical College14, University of Tokyo15, Nippon Medical School16, Osaka City University17, Hirosaki University18, Kurume University19, Niigata University20, Fukuoka University21, Kagoshima University22, Hyogo College of Medicine23
TL;DR: M E E T I N G OF T H E J A P A N E S E S O C I E T Y OF G A S T R O E N T E R O L O G Y March 28-30, 1991-Tokyo, Japan.
Abstract: M E E T I N G OF T H E J A P A N E S E S O C I E T Y OF G A S T R O E N T E R O L O G Y March 28-30, 1991-Tokyo, Japan Chairman: Yutaka MATSUO, M.D.