C
Catherine A. Steer
Researcher at University of British Columbia
Publications - 15
Citations - 1591
Catherine A. Steer is an academic researcher from University of British Columbia. The author has contributed to research in topics: Innate lymphoid cell & Inflammation. The author has an hindex of 11, co-authored 15 publications receiving 1284 citations. Previous affiliations of Catherine A. Steer include BC Cancer Agency & University of California, San Francisco.
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Journal ArticleDOI
Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation.
Timotheus Y.F. Halim,Catherine A. Steer,Laura Mathä,Matthew J. Gold,Itziar Martinez-Gonzalez,Kelly M. McNagny,Andrew N. J. McKenzie,Fumio Takei,Fumio Takei +8 more
TL;DR: It is shown that group 2 innate lymphoid cells (ILC2s) are required to mount a robust Th2 cell response to the protease-allergen papain, suggesting a common pathway in the initiation of Th 2 cell responses to allergen.
Journal ArticleDOI
Allergen-Experienced Group 2 Innate Lymphoid Cells Acquire Memory-like Properties and Enhance Allergic Lung Inflammation
Itziar Martinez-Gonzalez,Itziar Martinez-Gonzalez,Laura Mathä,Laura Mathä,Catherine A. Steer,Catherine A. Steer,Maryam Ghaedi,Maryam Ghaedi,Grace F. T. Poon,Grace F. T. Poon,Fumio Takei,Fumio Takei +11 more
TL;DR: The allergen-experienced ILC2s exhibited a gene expression profile similar to that of memory T cells, which may explain why asthma patients are often sensitized to multiple allergens.
Journal ArticleDOI
Type 2 innate lymphoid cells disrupt bronchial epithelial barrier integrity by targeting tight junctions through IL-13 in asthmatic patients.
Kazunari Sugita,Kazunari Sugita,Catherine A. Steer,Itziar Martinez-Gonzalez,Can Altunbulakli,Hideaki Morita,Francesc Castro-Giner,Francesc Castro-Giner,Terufumi Kubo,Paulina Wawrzyniak,Beate Rückert,Katsuko Sudo,Susumu Nakae,Susumu Nakae,Kenji Matsumoto,Liam O'Mahony,Mübeccel Akdis,Fumio Takei,Cezmi A. Akdis +18 more
TL;DR: It is demonstrated that ILC2s are responsible for bronchial epithelial TJ barrier leakiness through IL‐13, highlighting an essential mechanism in asthma pathogenesis.
Journal ArticleDOI
Lung ILC2s link innate and adaptive responses in allergic inflammation
TL;DR: A common pathway wherein ILC2s, activated by the epithelium-derived cytokine IL-33, link the innate and the adaptive responses after allergen encounter in the lung is proposed.