C
Chufeng Li
Researcher at Arizona State University
Publications - 37
Citations - 1085
Chufeng Li is an academic researcher from Arizona State University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 26 publications receiving 709 citations. Previous affiliations of Chufeng Li include Wuhan University & University of Hamburg.
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Journal ArticleDOI
Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography
Jason R. Stagno,Yuan Liu,Yuba R. Bhandari,Chelsie E. Conrad,Subrata Panja,Monalisa Swain,Lixin Fan,Garrett Nelson,Chufeng Li,D.R. Wendel,Thomas A. White,Jesse Coe,Max O. Wiedorn,Juraj Knoska,Dominik Oberthuer,R.A. Tuckey,Ping Yu,Marzena A. Dyba,Sergey G. Tarasov,Uwe Weierstall,Thomas D. Grant,Charles D. Schwieters,Jiashan Zhang,Adrian R. Ferré-D'Amaré,Petra Fromme,D. E. Draper,Mengning Liang,Mark S. Hunter,Sébastien Boutet,Kemin Tan,Xiaobing Zuo,Xinhua Ji,Anton Barty,Nadia A. Zatsepin,Henry N. Chapman,John C. H. Spence,Sarah A. Woodson,Yun-Xing Wang +37 more
TL;DR: The potential of ‘mix-and-inject’ time-resolved serial crystallography to study biochemically important interactions between biomacromolecules and ligands, including those that involve large conformational changes, is demonstrated.
Journal ArticleDOI
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease.
Sebastian Günther,P. Reinke,Yaiza Fernández-García,J. Lieske,Thomas J. Lane,Helen M. Ginn,Faisal Hammad Mekky Koua,Christiane Ehrt,W. Ewert,Dominik Oberthuer,Oleksandr Yefanov,S. Meier,Kristina Lorenzen,Boris Krichel,Janine-Denise Kopicki,Luca Gelisio,W. Brehm,Ilona Dunkel,B. Seychell,Henry Gieseler,Brenna Norton-Baker,Brenna Norton-Baker,Beatriz Escudero-Pérez,M. Domaracky,S. Saouane,A. Tolstikova,Thomas A. White,Anna Hänle,M. Groessler,Holger Fleckenstein,F. Trost,M. Galchenkova,Y. Gevorkov,Chufeng Li,Salah Awel,Ariana Peck,Miriam Barthelmess,Frank Schlünzen,P. Lourdu Xavier,N. Werner,H. Andaleeb,N. Ullah,Sven Falke,Vasundara Srinivasan,Bruno Alves Franca,M. Schwinzer,Hévila Brognaro,Cromarte Rogers,D. Melo,Joanna J. Zaitseva-Doyle,Juraj Knoska,Gisel E. Peña-Murillo,Aida Rahmani Mashhour,V. Hennicke,Pontus Fischer,Johanna Hakanpää,Jan Meyer,Philip Gribbon,Bernhard Ellinger,Maria Kuzikov,Markus Wolf,Andrea R. Beccari,Gleb Bourenkov,David von Stetten,Guillaume Pompidor,Isabel Bento,Saravanan Panneerselvam,Ivars Karpics,Thomas R. Schneider,Maria Garcia-Alai,Stephan Niebling,Christian M. Günther,C. Schmidt,Robin Schubert,Huijong Han,J. Boger,Diana C. F. Monteiro,Linlin Zhang,Xinyuanyuan Sun,J. Pletzer-Zelgert,J. Wollenhaupt,Christian G. Feiler,Manfred S. Weiss,Eike C. Schulz,Pedram Mehrabi,Katarina Karničar,Aleksandra Usenik,Jure Loboda,Henning Tidow,Ashwin Chari,Rolf Hilgenfeld,Charlotte Uetrecht,Russell J. Cox,Andrea Zaliani,Tobias Beck,Matthias Rarey,Stephan Günther,Dušan Turk,Winfried Hinrichs,Winfried Hinrichs,Henry N. Chapman,Arwen R. Pearson,Christian Betzel,Alke Meents +103 more
TL;DR: In this article, a high-throughput x-ray crystallographic screen of two repurposing drug libraries against the SARS-CoV-2 main protease (Mpro), which is essential for viral replication, was performed.
Journal ArticleDOI
Native phasing of x-ray free-electron laser data for a G protein-coupled receptor.
Alexander Batyuk,Lorenzo Galli,Andrii Ishchenko,Gye Won Han,Cornelius Gati,Petr Popov,Petr Popov,Ming-Yue Lee,Benjamin Stauch,Thomas A. White,Anton Barty,Andrew Aquila,Mark S. Hunter,Mengning Liang,Sébastien Boutet,Mengchen Pu,Zhi-Jie Liu,Zhi-Jie Liu,Garrett Nelson,Daniel James,Chufeng Li,Yun Zhao,John C. H. Spence,Wei Liu,Petra Fromme,Vsevolod Katritch,Uwe Weierstall,Raymond C. Stevens,Vadim Cherezov +28 more
TL;DR: The ability to solve the crystallographic phase problem for SFX data collected with an XFEL using the anomalous signal from native sulfur atoms is demonstrated, leading to a bias-free room temperature structure of the human A2A adenosine receptor at 1.9 Å resolution.
Journal ArticleDOI
XFEL structures of the human MT2melatonin receptor reveal the basis of subtype selectivity.
Linda C. Johansson,Benjamin Stauch,John D. McCorvy,John D. McCorvy,Gye Won Han,Nilkanth Patel,Xi Ping Huang,Alexander Batyuk,Cornelius Gati,Cornelius Gati,Samuel T. Slocum,Chufeng Li,Jessica M. Grandner,Shuming Hao,Reid H.J. Olsen,Alexandra R. Tribo,Sahba Zaare,Lan Zhu,Nadia A. Zatsepin,Uwe Weierstall,Saïd Yous,Raymond C. Stevens,Wei Liu,Bryan L. Roth,Vsevolod Katritch,Vadim Cherezov +25 more
TL;DR: Structural and functional studies show that the MT2 melatonin receptor, unlike the MT1 receptor, contains an extracellular opening for ligand entry, shedding light on receptor subtype specificity.
Journal ArticleDOI
Lipidic cubic phase injector is a viable crystal delivery system for time-resolved serial crystallography
Przemyslaw Nogly,Valerie Panneels,Garrett Nelson,Cornelius Gati,Tetsunari Kimura,Christopher J. Milne,Despina Milathianaki,Minoru Kubo,Wenting Wu,Chelsie E. Conrad,Jesse Coe,Richard Bean,Yun Zhao,Petra Båth,Robert Dods,Rajiv Harimoorthy,Kenneth R. Beyerlein,Jan Rheinberger,Daniel James,Daniel P. DePonte,Chufeng Li,Leonardo Sala,Garth J. Williams,Mark S. Hunter,Jason E. Koglin,Peter Berntsen,Eriko Nango,So Iwata,Henry N. Chapman,Petra Fromme,Matthias Frank,Rafael Abela,Sébastien Boutet,Anton Barty,Thomas A. White,Uwe Weierstall,John C. H. Spence,Richard Neutze,Gebhard F. X. Schertler,Gebhard F. X. Schertler,Jörg Standfuss +40 more
TL;DR: This study provides an important step towards characterizing the complete photocycle dynamics of retinal proteins and demonstrates the feasibility of a sample efficient viscous medium jet for TR-SFX.