K
Kenneth J. Pienta
Researcher at Johns Hopkins University School of Medicine
Publications - 751
Citations - 72579
Kenneth J. Pienta is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 127, co-authored 671 publications receiving 64531 citations. Previous affiliations of Kenneth J. Pienta include Rutgers University & Harper University Hospital.
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Significance of gleason pattern 4 as an independent prognostic indicator of postoperative psa failure in prostatic adenocarcinoma
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Neuropilin-2 regulates androgen-receptor transcriptional activity in advanced prostate cancer
Samikshan Dutta,Navatha Shree Polavaram,Ridwan Islam,Sreyashi Bhattacharya,Sanika Bodas,Thomas Mayr,Sohini B. Roy,Sophie Alvarez Y. Albala,Marieta Toma,Anza Darehshouri,Angelika Borkowetz,Stefanie Conrad,Susanne Fuessel,Manfred P. Wirth,Gustavo B. Baretton,Lorenz C. Hofbauer,Paramita M. Ghosh,Kenneth J. Pienta,David Klinkebiel,Surinder K. Batra,Michael H. Muders,Kaustubh Datta +21 more
TL;DR: In this paper , a specific splice variant of NRP2 becomes sumoylated upon ligand stimulation and translocates to the inner nuclear membrane, which stabilizes the complex between AR and nuclear pore proteins to promote CRPC specific gene expression.
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Targeting interleukin 4 receptor alpha on tumor-associated macrophages reduces the pro-tumor macrophage phenotype
Amber E. de Groot,Kayla V. Myers,Timothy E. G. Krueger,W. Nathaniel Brennen,Sarah R. Amend,Kenneth J. Pienta +5 more
TL;DR: In this paper , the IL-4R alpha antagonist antibody Dupilumab (Dupixent) was used to reduce M2-like macrophage features, including a shift in cell surface marker protein expression and gene expression.
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Advancements in the identification of EV derived mRNA biomarkers for liquid biopsy of clear cell renal cell carcinomas
TL;DR: In this paper, the authors used Extracellular Vesicle (EV)-derived mRNA as a potential diagnostic biomarker detecting the presence of clear cell renal cell carcinoma (ccRCC).
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Prospective evaluation of 68Ga-PSMA-11 PET/CT in Chinese men with biochemical recurrence after radical prostatectomy for prostate cancer: relationships between location of recurrence, time after prostatectomy, and serum PSA level
Liang Dong,Liang Dong,Yinjie Zhu,Mei Xin,Baijun Dong,Jiahua Pan,Jianjun Liu,Sarah R. Amend,Wei Xue,Kenneth J. Pienta,Steven P. Rowe +10 more
TL;DR: Adding value for the detection of lesions compatible with sites of PCa was found with 68Ga-PSMA-11 PET/CT over conventional imaging, and the observed patterns of disease spread may have implications for understanding the biology of early prostate cancer metastasis.