Kenneth J. Pienta

TL;DR: The Tilman equations for modeling the invasion of two species into a defined space have been modified to study the invasionOf cancer cells into the bone marrow microenvironment to allow a more flexible way to model the space competition between the two cell species.

TL;DR: This data suggests that ERG IHC may be less sensitive for ERG rearrangements in castration‐resistant prostate cancer (CRPC), so a cohort of rapid autopsy patients with lethal metastatic CRPC with high ERG protein expression was sought.

TL;DR: It is reported that MTDH is amplified frequently in human prostate cancers where its expression levels are tightly correlated with prostate cancer progression and poor disease-free survival, and direct silencing of Mtdh in prostate cancer cells decreased proliferation in vitro and tumor growth in vivo, supporting an epithelial cell-intrinsic role of MTDH in prostatecancer.

TL;DR: The authors evaluated the combination of oral cyclophosphamide, oral prednisone, and diethylstilbestrol in patients with androgen‐independent prostate carcinoma (AIPC).

TL;DR: A role for Wnt signaling as a driver of prostate cancer bone metastatic tropism and invasion is revealed and small molecule inhibition of JNK, which is an important component of the noncanonical WNT signaling pathway, significantly inhibited CM-mediated tumor invasion.