K
Kenneth J. Pienta
Researcher at Johns Hopkins University School of Medicine
Publications - 751
Citations - 72579
Kenneth J. Pienta is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 127, co-authored 671 publications receiving 64531 citations. Previous affiliations of Kenneth J. Pienta include Rutgers University & Harper University Hospital.
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Definitions of disease burden across the spectrum of metastatic castration-sensitive prostate cancer: comparison by disease outcomes and genomics
Philip A. Sutera,Kim Van der Eecken,Amar U. Kishan,Anis A. Hamid,Emily Grist,Gerhardt Attard,Tamara L. Lotan,Adrianna A. Mendes,Channing J. Paller,Michael A. Carducci,Ashley E. Ross,Haiyan Wang,Kenneth J. Pienta,Felix Y. Feng,Emmanuel S. Antonarakis,Piet Ost,Danny Y. Song,Stephen Greco,Curtiland Deville,T. Deweese,Phuoc T. Tran,Matthew P. Deek +21 more
TL;DR: In this article , the authors performed a retrospective review of patients with biochemically recurrent or mCSPC whose tumors underwent somatic targeted sequencing and classified patients into low and high-volume disease per CHAARTED, STAMPEDE, and two numeric (≤3 and ≤5) definitions.
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Integrated Multimodal Imaging of Dynamic Bone-Tumor Alterations Associated with Metastatic Prostate Cancer
Jean-Christophe Brisset,Benjamin A. Hoff,Thomas L. Chenevert,Jon A. Jacobson,Jennifer L. Boes,Stefanie Galbán,Alnawaz Rehemtulla,Timothy D. Johnson,Kenneth J. Pienta,Craig J. Galbán,Charles R. Meyer,Timothy Schakel,Klaas Nicolay,Ajjai Alva,Maha Hussain,Brian D. Ross +15 more
TL;DR: Voxel-based analysis of diffusion-weighted MRI and CT scans is used to simultaneously evaluate temporal changes in normal bone homeostasis along with prostate bone metatastsis to deliver an improved understanding of the spatiotemporal local microenvironment.
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A prospective phase II/III multicenter study of PSMA-targeted 18F-DCFPyL PET/CT imaging in patients with prostate cancer (OSPREY): A sub-analysis of regional and distant metastases detection rates at initial staging by 18F-DCFPyL PET/CT.
Frédéric Pouliot,Peter R. Carroll,Stephan Probst,Kenneth J. Pienta,Steven P. Rowe,Lawrence Saperstein,Barry A. Siegel,Akash Patnaik,Mark A. Preston,Ajjai Alva,Michael A. Gorin,Michael J. Morris +11 more
TL;DR: A novel approach called PSMA-based imaging is considered highly promising for the initial staging of men at risk of harboring occult metastatic prostate cancer (PCa) and it shows promising results in animals and men.
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Imaging and Characterization of Macrophage Distribution in Mouse Models of Human Prostate Cancer
Ben T. Copeland,Ben T. Copeland,Hassan Shallal,Chentian Shen,Kenneth J. Pienta,Catherine A. Foss,Martin G. Pomper +6 more
TL;DR: Prostate TAM disposition can be imaged ex vivo and is associated with growth characteristics of a variety of tumor subtypes regardless of PSMA or AR expression.
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The role of the nuclear matrix in cancer chemotherapy.
TL;DR: The nuclear matrix is the site of many nuclear functions including transcription, replication, formation of chromatin loops, and control of DNA supercoiling, and it contains various structural and functional components that represent targets for antineoplastic agents.