Kenneth J. Pienta

TL;DR: This is the first known study examining both gene copy number and whole genome CpG island methylation status in metastatic CRPC, suggesting that inactivation of this tumor suppressor through multiple pathways is critical to tumor cell survival.

TL;DR: Early bone disseminated prostate cancer cells in murine xenograft models can be enriched by lineage depletion, identified by human leukocyte antigen, and subsequently isolated and characterized by flow cytometry, suggesting a proclivity for bone dissemination by CD133+/CD44+ prostate cancer stem cells and a possible role for these cells as DTCs responsible for biochemical failure after curative prostatectomy.

TL;DR: This reply is in response to a Comment posed by Eibl on a paper to present a new adhesion measurement tool, and it is believed that meaningful results can be inferred by chemical cross-linking as explained below.

TL;DR: This study concludes that activation of p53 by potent and specific small-molecule MDM2 inhibitors is selectively toxic to tumors without causing damage to normal tissues, and provides a strong rationale to advance MI-219 or its analogues for clinical development as a new and promising cancer therapeutic strategy.

TL;DR: The remarkable diagnostic accuracy of PSMA-PET is reshaping prostate cancer imaging and the modularity of these agents hint at exciting new diagnostic and therapeutic opportunities that have the potential to improve the care of patients with prostate cancer as a whole.