K
Kenneth J. Pienta
Researcher at Johns Hopkins University School of Medicine
Publications - 751
Citations - 72579
Kenneth J. Pienta is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 127, co-authored 671 publications receiving 64531 citations. Previous affiliations of Kenneth J. Pienta include Rutgers University & Harper University Hospital.
Papers
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Journal ArticleDOI
The issues with tissues: the wide range of cell fate separation enables the evolution of multicellularity and cancer.
TL;DR: How the wide separation of cell phenotypes may contribute to cancer evolution is discussed, and how some tissues and organisms maintain high cell proliferation and plasticity without developing tumours at a corresponding rate demonstrates a potential proliferation paradox that requires further explanation.
Journal ArticleDOI
A phase II evaluation of oral tamoxifen and intermittent intravenous vinblastine in hormone-refractory adenocarcinoma of the prostate.
TL;DR: The dosage and schedule of vinblastine and tamoxifen used in this study is inactive in the treatment of metastatic hormone refractory prostate cancer.
Book ChapterDOI
Explaining Aberrations of Cell Structure and Cell Signaling in Cancer Using Complex Adaptive Systems
Eric D. Schwab,Kenneth J. Pienta +1 more
TL;DR: Several signal transduction pathways and cellular structures will be examined using a bottom-up approach to gain a better understanding of how structure and function are interrelated.
Journal ArticleDOI
Cancer dormancy and criticality from a game theory perspective
Amy Wu,David Liao,Vlamimir Kirilin,Ke-Chih Lin,Gonzalo Torga,Junle Qu,Liyu Liu,James C. Sturm,Kenneth J. Pienta,Robert H. Austin +9 more
TL;DR: In this article, the authors explore the dynamics of host-cancer cell populations in the presence of payoffs gradients and perturbations due to cell migration, and determine to what extent the time-dependence of the populations can be quantitively understood in spite of the underlying complexity of the individual agents and model the phenomena of dormancy.
Journal ArticleDOI
OC-0505: Interim results of a randomized trial of observation versus SABR for oligometastatic prostate cancer
Phuoc T. Tran,Noura Radwan,Ryan Phillips,Ashley E. Ross,Steven P. Rowe,Michael A. Gorin,Emmanuel S. Antonarakis,Curtiland Deville,Stephen Greco,Samuel R. Denmeade,Channing J. Paller,Danny Y. Song,Maximilian Diehn,Hao Wang,Michael A. Carducci,Kenneth J. Pienta,Martin G. Pomper,T. DeWeese,Adam P. Dicker,Mario A. Eisenberger +19 more