K
Kenneth J. Pienta
Researcher at Johns Hopkins University School of Medicine
Publications - 751
Citations - 72579
Kenneth J. Pienta is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 127, co-authored 671 publications receiving 64531 citations. Previous affiliations of Kenneth J. Pienta include Rutgers University & Harper University Hospital.
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Journal ArticleDOI
The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex
John R. Prensner,Matthew K. Iyer,Anirban Sahu,Irfan A. Asangani,Qi Cao,Lalit Patel,Ismael A. Vergara,Elai Davicioni,Nicholas Erho,Mercedeh Ghadessi,Robert B. Jenkins,Timothy J. Triche,Rohit Malik,Rachel Bedenis,Natalie McGregor,Teng Ma,Wei Chen,Sumin Han,Xiaojun Jing,Xuhong Cao,Xiaoju Wang,Benjamin C. Chandler,Wei Yan,Javed Siddiqui,Lakshmi P. Kunju,Saravana M. Dhanasekaran,Kenneth J. Pienta,Felix Y. Feng,Arul M. Chinnaiyan +28 more
TL;DR: It is suggested that SChLAP1 contributes to the development of lethal cancer at least in part by antagonizing the tumor-suppressive functions of the SWI/SNF complex.
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Outcomes of Observation vs Stereotactic Ablative Radiation for Oligometastatic Prostate Cancer: The ORIOLE Phase 2 Randomized Clinical Trial
Ryan Phillips,William Shi,Matthew P. Deek,Noura Radwan,Su Jin Lim,Emmanuel S. Antonarakis,Steven P. Rowe,Ashley E. Ross,Michael A. Gorin,Curtiland Deville,Stephen Greco,Hailun Wang,Samuel R. Denmeade,Channing J. Paller,Shirl Dipasquale,Theodore L. DeWeese,Danny Y. Song,Hao Wang,Michael A. Carducci,Kenneth J. Pienta,Martin G. Pomper,Adam P. Dicker,Mario A. Eisenberger,Ash A. Alizadeh,Maximilian Diehn,Phuoc T. Tran +25 more
TL;DR: This randomized clinical trial assesses whether treatment with stereotactic ablative radiotherapy vs observation improves oncologic outcomes in men with recurrent hormone-sensitive oligometastatic prostate cancer.
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Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC38 trial data.
Howard I. Scher,Howard I. Scher,Xiaoyu Jia,Johann S. de Bono,Martin Fleisher,Kenneth J. Pienta,Derek Raghavan,Glenn Heller +7 more
TL;DR: CTC number, analysed as a continuous variable, can be used to monitor disease status and might be useful as an intermediate endpoint of survival in clinical trials.
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Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters.
Kevin J. Cheung,Veena Padmanaban,Vanesa L. Silvestri,Koen Schipper,Joshua D. Cohen,Amanda N. Fairchild,Michael A. Gorin,James E. Verdone,Kenneth J. Pienta,Joel S. Bader,Andrew J. Ewald +10 more
TL;DR: K14 is revealed as a key regulator of metastasis and the concept that K14+ epithelial tumor cell clusters disseminate collectively to colonize distant organs is established, to enable novel prognostics and therapies to improve patient outcomes.
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CCL2 and interleukin-6 promote survival of human CD11b+ peripheral blood mononuclear cells and induce M2-type macrophage polarization.
TL;DR: A role for CCL2 and IL-6 in the survival of myeloid monocytes recruited to the tumor microenvironment and their differentiation toward tumor-promoting M2-type macrophages via inhibition of caspase-8 cleavage and enhanced autophagy is suggested.