K
Kevin Hadi
Researcher at Cornell University
Publications - 9
Citations - 1963
Kevin Hadi is an academic researcher from Cornell University. The author has contributed to research in topics: Biology & Genome. The author has an hindex of 3, co-authored 5 publications receiving 1000 citations.
Papers
More filters
Journal ArticleDOI
Next-generation characterization of the Cancer Cell Line Encyclopedia
Mahmoud Ghandi,Franklin W. Huang,Franklin W. Huang,Franklin W. Huang,Judit Jané-Valbuena,Judit Jané-Valbuena,Gregory V. Kryukov,Christopher Lo,E. Robert McDonald,Jordi Barretina,Ellen Gelfand,Craig M. Bielski,Haoxin Li,Haoxin Li,Kevin Hu,Alexander Y. Andreev-Drakhlin,Jaegil Kim,Julian M. Hess,Brian J. Haas,François Aguet,Barbara A. Weir,Michael V. Rothberg,Brenton R. Paolella,Michael S. Lawrence,Rehan Akbani,Yiling Lu,Hong L. Tiv,Prafulla C. Gokhale,Antoine de Weck,Ali Amin Mansour,Coyin Oh,Juliann Shih,Kevin Hadi,Yanay Rosen,Jonathan Bistline,Kavitha Venkatesan,Anupama Reddy,Dmitriy Sonkin,Dmitriy Sonkin,Manway Liu,Joseph Lehar,Joshua M. Korn,Dale Porter,Michael D. Jones,Javad Golji,Giordano Caponigro,Jordan E. Taylor,Caitlin M. Dunning,Amanda L. Creech,Allison Warren,James M. McFarland,Mahdi Zamanighomi,Audrey Kauffmann,Nicolas Stransky,Marcin Imielinski,Yosef E. Maruvka,Yosef E. Maruvka,Andrew D. Cherniack,Andrew D. Cherniack,Aviad Tsherniak,Francisca Vazquez,Jacob D. Jaffe,Andrew A. Lane,David M. Weinstock,Cory M. Johannessen,Michael Morrissey,Frank Stegmeier,Robert Schlegel,William C. Hahn,William C. Hahn,Gad Getz,Gordon B. Mills,Jesse S. Boehm,Todd R. Golub,Todd R. Golub,Todd R. Golub,Levi A. Garraway,Levi A. Garraway,William R. Sellers,William R. Sellers +79 more
TL;DR: The original Cancer Cell Line Encyclopedia is expanded with deeper characterization of over 1,000 cell lines, including genomic, transcriptomic, and proteomic data, and integration with drug-sensitivity and gene-dependency data, which reveals potential targets for cancer drugs and associated biomarkers.
Journal ArticleDOI
Distinct Classes of Complex Structural Variation Uncovered across Thousands of Cancer Genome Graphs.
Kevin Hadi,Xiaotong Yao,Julie M. Behr,Aditya Deshpande,Charalampos Xanthopoulakis,Huasong Tian,Sarah Kudman,Joel Rosiene,Madison Darmofal,Joseph DeRose,Rick Mortensen,Emily M. Adney,Alon Shaiber,Zoran Gajic,Michael Sigouros,Kenneth Eng,Jeremiah Wala,Jeremiah Wala,Jeremiah Wala,Kazimierz O. Wrzeszczynski,Kanika Arora,Minita Shah,Anne-Katrin Emde,Vanessa Felice,Mayu O. Frank,Robert B. Darnell,Mahmoud Ghandi,Franklin W. Huang,Franklin W. Huang,Sally M. Dewhurst,John Maciejowski,Titia de Lange,Jeremy Setton,Nadeem Riaz,Jorge S. Reis-Filho,Simon N. Powell,David A. Knowles,Ed Reznik,Bud Mishra,Rameen Beroukhim,Rameen Beroukhim,Michael C. Zody,Nicolas Robine,Kenji Oman,Carissa A. Sanchez,Mary K. Kuhner,Lucian P. Smith,Patricia C. Galipeau,Thomas G. Paulson,Brian J. Reid,Brian J. Reid,Xiaohong Li,David Wilkes,Andrea Sboner,Juan Miguel Mosquera,Olivier Elemento,Marcin Imielinski +56 more
TL;DR: Clustering of tumors according to genome graph-derived features identified subgroups associated with DNA repair defects and poor prognosis and uncovered three novel complex rearrangement phenomena: pyrgo, rigma, and tyfonas.
Posted ContentDOI
Novel patterns of complex structural variation revealed across thousands of cancer genome graphs
Kevin Hadi,Xiaotong Yao,Julie M. Behr,Aditya Deshpande,Xanthopoulakis C,Joel Rosiene,Darmofal M,Huasong Tian,DeRose J,Mortensen R,Emily M. Adney,Zoran Gajic,Kenneth Eng,Jeremiah Wala,Jeremiah Wala,Jeremiah Wala,Kazimierz O. Wrzeszczynski,Kanika Arora,Minita Shah,Anne-Katrin Emde,Felice,Mayu O. Frank,Robert B. Darnell,Mahmoud Ghandi,Franklin W. Huang,Franklin W. Huang,John Maciejowski,de Lange T,Jeremy Setton,Nadeem Riaz,Jorge S. Reis-Filho,Simon N. Powell,David A. Knowles,Ed Reznik,Bud Mishra,Rameen Beroukhim,Rameen Beroukhim,Michael C. Zody,Nicolas Robine,Kenji Oman,Carissa A. Sanchez,Kuhner Mk,Smith Lp,Patricia C. Galipeau,Thomas G. Paulson,Brian J. Reid,Xiaohong Li,David Wilkes,Andrea Sboner,Juan Miguel Mosquera,Olivier Elemento,Marcin Imielinski +51 more
TL;DR: Clustering of tumors according to genome graph-derived features identifies subgroups associated with DNA repair defects and poor prognosis using a novel genome graph computational paradigm.
Posted ContentDOI
Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas
Andrew L.H. Webster,Mathijs A. Sanders,Mathijs A. Sanders,Krupa R. Patel,Ralf Dietrich,Raymond J. Noonan,Francis P. Lach,Ryan R. White,Audrey Goldfarb,Kevin Hadi,Matthew M. Edwards,Frank X. Donovan,Moonjung Jung,Sunandini Sridhar,Olivier Fedrigo,Huasong Tian,Joel Rosiene,Thomas Heineman,Jennifer A. Kennedy,Jennifer A. Kennedy,Lorenzo Bean,Ozgur Rosti,Rebecca Tryon,Ashlyn-Maree Gonzalez,Allana Rosenberg,Ji-Dung Luo,Thomas Carrol,Eunike Velleuer,Jeffrey C. Rastatter,Susanne I. Wells,Jordi Surrallés,Grover C. Bagby,Margaret L. MacMillan,John E. Wagner,Maria Cancio,Farid Boulad,Theresa Scognamiglio,Roger D. Vaughan,Amnon Koren,Marcin Imielinski,Settara C. Chandrasekharappa,Arleen D. Auerbach,Bhuvanesh Singh,David I. Kutler,Peter J. Campbell,Agata Smogorzewska +45 more
TL;DR: Fanconi anemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink (ICL) repair resulting in chromosome breakage as discussed by the authors.
Journal ArticleDOI
Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer.
Andrew L. H. Webster,Mathijs A. Sanders,Krupa B. Patel,Ralf Dietrich,Raymond J. Noonan,Francis P. Lach,Ryan R. White,Audrey Goldfarb,Kevin Hadi,Matthew M. Edwards,Frank X. Donovan,Remco Hoogenboezem,Moonjung Jung,Sunandini Sridhar,Tom Wiley,Olivier Fedrigo,Huasong Tian,Joel Rosiene,Thomas E. Heineman,Jennifer A. Kennedy,Lorenzo Bean,Rasim Ozgur Rosti,Rebecca Tryon,Ashlyn Gonzalez,A. Rosenberg,Jizheng Luo,Thomas L. Carroll,S. Shroff,Michael Beaumont,Eunike Velleuer,Jeffrey C. Rastatter,Susanne I. Wells,Jordi Surrallés,Grover C. Bagby,Margaret L. MacMillan,John E. Wagner,Maria I Cancio,Farid Boulad,Theresa Scognamiglio,R. Vaughan,Kristin G. Beaumont,Amnon Koren,Marcin Imielinski,Settara C. Chandrasekharappa,Arleen D. Auerbach,Bhuvanesh Singh,David I. Kutler,Peter J. Campbell,Agata Smogorzewska +48 more
TL;DR: Fanconi anaemia (FA), a model syndrome of genome instability, is caused by a deficiency in DNA interstrand crosslink repair resulting in chromosome breakage as mentioned in this paper , which can lead to epithelial-to-mesenchymal transition and enhanced keratinocyte-intrinsic inflammatory signalling.