H
Hong L. Tiv
Researcher at Harvard University
Publications - 14
Citations - 2105
Hong L. Tiv is an academic researcher from Harvard University. The author has contributed to research in topics: Midostaurin & Tyrosine kinase. The author has an hindex of 8, co-authored 14 publications receiving 1123 citations.
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Journal ArticleDOI
Next-generation characterization of the Cancer Cell Line Encyclopedia
Mahmoud Ghandi,Franklin W. Huang,Franklin W. Huang,Franklin W. Huang,Judit Jané-Valbuena,Judit Jané-Valbuena,Gregory V. Kryukov,Christopher Lo,E. Robert McDonald,Jordi Barretina,Ellen Gelfand,Craig M. Bielski,Haoxin Li,Haoxin Li,Kevin Hu,Alexander Y. Andreev-Drakhlin,Jaegil Kim,Julian M. Hess,Brian J. Haas,François Aguet,Barbara A. Weir,Michael V. Rothberg,Brenton R. Paolella,Michael S. Lawrence,Rehan Akbani,Yiling Lu,Hong L. Tiv,Prafulla C. Gokhale,Antoine de Weck,Ali Amin Mansour,Coyin Oh,Juliann Shih,Kevin Hadi,Yanay Rosen,Jonathan Bistline,Kavitha Venkatesan,Anupama Reddy,Dmitriy Sonkin,Dmitriy Sonkin,Manway Liu,Joseph Lehar,Joshua M. Korn,Dale Porter,Michael D. Jones,Javad Golji,Giordano Caponigro,Jordan E. Taylor,Caitlin M. Dunning,Amanda L. Creech,Allison Warren,James M. McFarland,Mahdi Zamanighomi,Audrey Kauffmann,Nicolas Stransky,Marcin Imielinski,Yosef E. Maruvka,Yosef E. Maruvka,Andrew D. Cherniack,Andrew D. Cherniack,Aviad Tsherniak,Francisca Vazquez,Jacob D. Jaffe,Andrew A. Lane,David M. Weinstock,Cory M. Johannessen,Michael Morrissey,Frank Stegmeier,Robert Schlegel,William C. Hahn,William C. Hahn,Gad Getz,Gordon B. Mills,Jesse S. Boehm,Todd R. Golub,Todd R. Golub,Todd R. Golub,Levi A. Garraway,Levi A. Garraway,William R. Sellers,William R. Sellers +79 more
TL;DR: The original Cancer Cell Line Encyclopedia is expanded with deeper characterization of over 1,000 cell lines, including genomic, transcriptomic, and proteomic data, and integration with drug-sensitivity and gene-dependency data, which reveals potential targets for cancer drugs and associated biomarkers.
Journal ArticleDOI
Inhibition of USP10 induces degradation of oncogenic FLT3
Ellen Weisberg,Nathan J. Schauer,Jing Yang,Ilaria Lamberto,Laura M. Doherty,Shruti Bhatt,Atsushi Nonami,Chengcheng Meng,Anthony Letai,Renee Wright,Hong L. Tiv,Prafulla C. Gokhale,Maria Stella Ritorto,Virginia De Cesare,Matthias Trost,Alexandra N. Christodoulou,Amanda L. Christie,David M. Weinstock,Sophia Adamia,Richard Stone,Dharminder Chauhan,Kenneth C. Anderson,Hyuk-Soo Seo,Sirano Dhe-Paganon,Martin Sattler,Nathanael S. Gray,James D. Griffin,Sara J. Buhrlage +27 more
TL;DR: Targeting of USP10 showed efficacy in preclinical models of mutant- FLT3 AML, including cell lines, primary patient specimens and mouse models of oncogenic-FLT3-driven leukemia.
Journal ArticleDOI
MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors
Thomas P. Howard,Taylor E. Arnoff,Melinda R. Song,Andrew O. Giacomelli,Andrew O. Giacomelli,Xiaofeng Wang,Andrew L. Hong,Andrew L. Hong,Neekesh V. Dharia,Neekesh V. Dharia,Su Wang,Francisca Vazquez,Minh-Tam Pham,Ann M. Morgan,Franziska Wachter,Gregory H. Bird,Guillaume Kugener,Elaine M. Oberlick,Elaine M. Oberlick,Matthew G. Rees,Hong L. Tiv,Justin H. Hwang,Justin H. Hwang,Katherine H. Walsh,Katherine H. Walsh,April Cook,April Cook,John M. Krill-Burger,Aviad Tsherniak,Prafulla C. Gokhale,Peter J. Park,Kimberly Stegmaier,Kimberly Stegmaier,Loren D. Walensky,William C. Hahn,William C. Hahn,Charles W. M. Roberts +36 more
TL;DR: Together, these studies identify a genetic connection between mutations in the SWI/SNF chromatin-remodeling complex and the tumor suppressor gene TP53 and provide preclinical evidence to support the targeting of MDM2 and MDM4 in this often-fatal pediatric cancer.
Journal ArticleDOI
A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers.
Stephanie Guerra,Stephanie Guerra,Ophélia Maertens,Ophélia Maertens,Ryan Kuzmickas,Ryan Kuzmickas,Thomas De Raedt,Thomas De Raedt,Richard O. Adeyemi,Richard O. Adeyemi,Caroline J. Guild,Caroline J. Guild,Shawna Guillemette,Shawna Guillemette,Amanda J. Redig,Emily S. Chambers,Man Xu,Hong L. Tiv,Sandro Santagata,Sandro Santagata,Pasi A. Jänne,Stephen J. Elledge,Karen Cichowski,Karen Cichowski +23 more
TL;DR: It is reported that half of KRAS-mutant NSCLCs aberrantly express the homeobox protein HOXC10, largely due to unappreciated defects in PRC2, which confers sensitivity to combined BET/MEK inhibitors in xenograft and PDX models.
Journal ArticleDOI
Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia.
Koshi Akahane,Koshi Akahane,Zhaodong Li,Julia Etchin,Alla Berezovskaya,Evisa Gjini,Craig E. Masse,Wenyan Miao,Jennifer Rocnik,Rosana Kapeller,Jeremy R. Greenwood,Hong L. Tiv,Takaomi Sanda,David M. Weinstock,A. Thomas Look,A. Thomas Look +15 more
TL;DR: Investigation revealed that NDI‐031301 treatment uniquely leads to activation of three mitogen‐activated protein kinases (MAPKs), resulting in phosphorylation of ERK, SAPK/JNK and p38 MAPK coincident with PARP cleavage, support selective inhibition of TYK2 as a promising potential therapeutic strategy for T‐ALL.