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Brenton R. Paolella
Researcher at Broad Institute
Publications - 33
Citations - 2962
Brenton R. Paolella is an academic researcher from Broad Institute. The author has contributed to research in topics: Cancer & Cancer cell. The author has an hindex of 13, co-authored 29 publications receiving 1705 citations. Previous affiliations of Brenton R. Paolella include Harvard University & Dartmouth College.
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Journal ArticleDOI
Next-generation characterization of the Cancer Cell Line Encyclopedia
Mahmoud Ghandi,Franklin W. Huang,Franklin W. Huang,Franklin W. Huang,Judit Jané-Valbuena,Judit Jané-Valbuena,Gregory V. Kryukov,Christopher Lo,E. Robert McDonald,Jordi Barretina,Ellen Gelfand,Craig M. Bielski,Haoxin Li,Haoxin Li,Kevin Hu,Alexander Y. Andreev-Drakhlin,Jaegil Kim,Julian M. Hess,Brian J. Haas,François Aguet,Barbara A. Weir,Michael V. Rothberg,Brenton R. Paolella,Michael S. Lawrence,Rehan Akbani,Yiling Lu,Hong L. Tiv,Prafulla C. Gokhale,Antoine de Weck,Ali Amin Mansour,Coyin Oh,Juliann Shih,Kevin Hadi,Yanay Rosen,Jonathan Bistline,Kavitha Venkatesan,Anupama Reddy,Dmitriy Sonkin,Dmitriy Sonkin,Manway Liu,Joseph Lehar,Joshua M. Korn,Dale Porter,Michael D. Jones,Javad Golji,Giordano Caponigro,Jordan E. Taylor,Caitlin M. Dunning,Amanda L. Creech,Allison Warren,James M. McFarland,Mahdi Zamanighomi,Audrey Kauffmann,Nicolas Stransky,Marcin Imielinski,Yosef E. Maruvka,Yosef E. Maruvka,Andrew D. Cherniack,Andrew D. Cherniack,Aviad Tsherniak,Francisca Vazquez,Jacob D. Jaffe,Andrew A. Lane,David M. Weinstock,Cory M. Johannessen,Michael Morrissey,Frank Stegmeier,Robert Schlegel,William C. Hahn,William C. Hahn,Gad Getz,Gordon B. Mills,Jesse S. Boehm,Todd R. Golub,Todd R. Golub,Todd R. Golub,Levi A. Garraway,Levi A. Garraway,William R. Sellers,William R. Sellers +79 more
TL;DR: The original Cancer Cell Line Encyclopedia is expanded with deeper characterization of over 1,000 cell lines, including genomic, transcriptomic, and proteomic data, and integration with drug-sensitivity and gene-dependency data, which reveals potential targets for cancer drugs and associated biomarkers.
Journal ArticleDOI
BET-bromodomain inhibition of MYC-amplified Medulloblastoma
Pratiti Bandopadhayay,Guillaume Bergthold,Brian Nguyen,Simone Schubert,Sharareh Gholamin,Yujie Tang,Sara Bolin,Steven E. Schumacher,Rhamy Zeid,Sabran Masoud,Furong Yu,Nujsaubnusi Vue,William J. Gibson,Brenton R. Paolella,Siddhartha Mitra,Samuel H. Cheshier,Jun Qi,Kun Wei Liu,Robert J. Wechsler-Reya,William A. Weiss,Fredrik J. Swartling,Mark W. Kieran,James E. Bradner,Rameen Beroukhim,Yoon Jae Cho +24 more
TL;DR: JQ1 suppresses MYC expression and MYC-associated transcriptional activity in medulloblastomas, resulting in an overall decrease in medULLoblastoma cell viability, which highlights the promise of BET bromodomain inhibitors as novel agents for MyC-amplified medullOBlastoma.
Journal ArticleDOI
MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism.
Pratiti Bandopadhayay,Pratiti Bandopadhayay,Lori A. Ramkissoon,Payal Jain,Guillaume Bergthold,Guillaume Bergthold,Jeremiah Wala,Jeremiah Wala,Rhamy Zeid,Steven E. Schumacher,Steven E. Schumacher,Laura M. Urbanski,Ryan O’Rourke,Ryan O’Rourke,William J. Gibson,William J. Gibson,Kristine Pelton,Shakti Ramkissoon,Harry J. Han,Yuankun Zhu,Namrata Choudhari,Amanda Silva,Amanda Silva,Katie Boucher,Rosemary E. Henn,Yun Jee Kang,David S. Knoff,Brenton R. Paolella,Brenton R. Paolella,Adrianne Gladden-Young,Pascale Varlet,Mélanie Pagès,Peleg M. Horowitz,Alexander J. Federation,Hayley Malkin,Adam Tracy,Sara Seepo,Matthew D. Ducar,Paul Van Hummelen,Mariarita Santi,Anna Maria Buccoliero,Mirko Scagnet,Daniel C. Bowers,Caterina Giannini,Stéphanie Puget,Cynthia Hawkins,Uri Tabori,Almos Klekner,László Bognár,Peter C. Burger,Charles G. Eberhart,Fausto J. Rodriguez,D. Ashley Hill,Sabine Mueller,Daphne A. Haas-Kogan,Daphne A. Haas-Kogan,Joanna J. Phillips,Sandro Santagata,Charles D. Stiles,James E. Bradner,James E. Bradner,Nada Jabado,Alon Goren,Jacques Grill,Azra H. Ligon,Liliana Goumnerova,Angela J. Waanders,Phillip B. Storm,Mark W. Kieran,Keith L. Ligon,Keith L. Ligon,Rameen Beroukhim,Rameen Beroukhim,Adam C. Resnick +73 more
TL;DR: This work has identified MYB-QKI fusions as a specific and single candidate driver event in angiocentric gliomas and represents the first example of a single driver rearrangement simultaneously transforming cells via three genetic and epigenetic mechanisms in a tumor.
Journal ArticleDOI
Multiplexed single-cell transcriptional response profiling to define cancer vulnerabilities and therapeutic mechanism of action.
James M. McFarland,Brenton R. Paolella,Allison Warren,Kathryn Geiger-Schuller,Tsukasa Shibue,Michael V. Rothberg,Olena Kuksenko,William Colgan,Andrew Jones,Emily Chambers,Danielle Dionne,Samantha Bender,Brian M. Wolpin,Brian M. Wolpin,Mahmoud Ghandi,Itay Tirosh,Itay Tirosh,Orit Rozenblatt-Rosen,Jennifer Roth,Todd R. Golub,Aviv Regev,Andrew J. Aguirre,Francisca Vazquez,Aviad Tsherniak +23 more
TL;DR: MIX-Seq is developed, a method for multiplexed transcriptional profiling of post-perturbation responses across a mixture of samples with single- cell resolution, using SNP-based computational demultiplexing of single-cell RNA-sequencing data.
Journal ArticleDOI
Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability.
Brenton R. Paolella,William J. Gibson,Laura M. Urbanski,John A. Alberta,Travis I. Zack,Pratiti Bandopadhayay,Caitlin A. Nichols,Pankaj K. Agarwalla,Meredith Brown,Rebecca Lamothe,Yong Yu,Peter S. Choi,Peter S. Choi,Esther A. Obeng,Esther A. Obeng,Dirk Heckl,Guo Wei,Belinda Wang,Belinda Wang,Aviad Tsherniak,Francisca Vazquez,Barbara A. Weir,David E. Root,Glenn S. Cowley,Sara J. Buhrlage,Charles D. Stiles,Benjamin L. Ebert,Benjamin L. Ebert,William C. Hahn,Robin Reed,Rameen Beroukhim +30 more
TL;DR: A genome-scale shRNA viability screen in human cancer cell lines was used to systematically identify genes that are essential in the context of particular copy-number alterations (copy-number associated gene dependencies) and identify partial copy-loss of wild-type SF3B1 as a novel, non-driver cancer gene dependency.