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Kevin J Curran
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 5
Citations - 193
Kevin J Curran is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Chemotherapy & Cyclophosphamide. The author has an hindex of 2, co-authored 5 publications receiving 86 citations. Previous affiliations of Kevin J Curran include Cornell University.
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Journal ArticleDOI
Toxicity and response after CD19-specific CAR T-cell therapy in pediatric/young adult relapsed/refractory B-ALL
Kevin J Curran,Kevin J Curran,Steven P. Margossian,Steven P. Margossian,Nancy A. Kernan,Nancy A. Kernan,Lewis B. Silverman,Lewis B. Silverman,David A. Williams,David A. Williams,Neerav Shukla,Rachel Kobos,Christopher J. Forlenza,Peter G. Steinherz,Peter G. Steinherz,Susan E. Prockop,Susan E. Prockop,Farid Boulad,Farid Boulad,Barbara Spitzer,Barbara Spitzer,Maria Cancio,Maria Cancio,Jaap Jan Boelens,Andrew L. Kung,Yasmin Khakoo,Yasmin Khakoo,Victoria Szenes,Jae H. Park,Craig S. Sauter,Glenn Heller,Xiuyan Wang,Brigitte Senechal,Richard J. O'Reilly,Isabelle Riviere,Michel Sadelain,Renier J. Brentjens +36 more
TL;DR: The data supports the safety of CD19-specific CAR T cell therapy for R/R B-ALL and suggest that dose intensity of conditioning chemotherapy and minimal pre-treatment disease burden have a positive impact on response without a negative effect on toxicity.
Journal ArticleDOI
Low toxicity and favorable overall survival in relapsed/refractory B-ALL following CAR T cells and CD34-selected T-cell depleted allogeneic hematopoietic cell transplant.
Vanessa A Fabrizio,Vanessa A Fabrizio,Nancy A. Kernan,Nancy A. Kernan,Farid Boulad,Farid Boulad,Maria Cancio,Maria Cancio,Jennifer Allen,Meghan A. Higman,Steven P. Margossian,Steven P. Margossian,Audrey Mauguen,Susan E. Prockop,Susan E. Prockop,Andromachi Scaradavou,Andromachi Scaradavou,Niketa C. Shah,Barbara Spitzer,Barbara Spitzer,Elliot Stieglitz,Nicholas D. Yeager,Richard J. O'Reilly,Richard J. O'Reilly,Renier J. Brentjens,Jaap Jan Boelens,Kevin J Curran,Kevin J Curran +27 more
TL;DR: In this small cohort of patients, CAR T cells followed by a CD34-selected TCD allo-HSCT appears to result in less TRM and favorable OS when compared with unmodified allo,HSCT, which demonstrates the feasibility of this approach.
Journal ArticleDOI
Real-World Treatment of Pediatric Patients with Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia Using Tisagenlecleucel That Is out of Specification for Commercial Release
Jenna Rossoff,Christina Baggott,Snehit Prabhu,Holly L Pacenta,Christine L Phillips,Christine L Phillips,Heather E. Stefanski,Julie-An Talano,Amy Moskop,Steven P. Margossian,Michael R. Verneris,G.D. Myers,Nicole Karras,Patrick A. Brown,Muna Qayed,Michelle L. Hermiston,Prakash Satwani,Christa Krupski,Amy K. Keating,Rachel Wilcox,Cara A Rabik,Vanessa A Fabrizio,Vanessa A Fabrizio,Michael Kunicki,Vasant Chinnabhandar,A. Yasemin Goksenin,Kevin J Curran,Kevin J Curran,Crystal L. Mackall,Theodore W. Laetsch,Liora M. Schultz +30 more
TL;DR: This study seeks to evaluate outcomes in pediatric and young adult patients who received tisagenlecleucel via the Managed Access Program or a single-patient IND in the Pediatric Real World CAR Consortium.
Journal ArticleDOI
Post-Relapse Outcomes Following Tisagenlecleucel: Poor Survival, Despite Current Salvage Therapies: Results from the Pediatric Real World CAR Consortium (PRWCC)
Heather E. Stefanski,Michael R. Verneris,Anne Eaton,Christina Baggott,Snehit Prabhu,Holly L Pacenta,Christine L Phillips,Jenna Rossoff,Julie-An An Talano,Amy Moskop,Steven P. Margossian,Doug Myers,Nicole Karras,Patrick A. Brown,Muna Qayed,Michelle L. Hermiston,Prakash Satwani,M. Christa Krupski,Amy K. Keating,Rachel Wilcox,Cara A Rabik,Vanessa A Fabrizio,Vasant Chinnabhandar,Yasemin Goksenin,Kevin J Curran,Crystal L. Mackall,Theodore W. Laetsch,Liora M. Schultz +27 more
Journal ArticleDOI
Out-of-specification tisagenlecleucel does not compromise safety or efficacy in pediatric acute lymphoblastic leukemia.
Jenna Rossoff,Christina Baggott,Snehit Prabhu,Holly L Pacenta,Christine L Phillips,Christine L Phillips,Heather E. Stefanski,Julie-An Talano,Amy Moskop,Steven P. Margossian,Michael R. Verneris,G.D. Myers,Nicole Karras,Patrick A. Brown,Muna Qayed,Michelle L. Hermiston,Prakash Satwani,Christa Krupski,Amy K. Keating,Rachel Wilcox,Cara A Rabik,Vanessa A Fabrizio,Vanessa A Fabrizio,Michael Kunicki,Vasant Chinnabhandar,A. Yasemin Goksenin,Kevin J Curran,Kevin J Curran,Crystal L. Mackall,Theodore W. Laetsch,Theodore W. Laetsch,Theodore W. Laetsch,Liora M. Schultz +32 more