K
Kimie Fujita
Researcher at University of Shiga Prefecture
Publications - 39
Citations - 2506
Kimie Fujita is an academic researcher from University of Shiga Prefecture. The author has contributed to research in topics: Asthma & Single-nucleotide polymorphism. The author has an hindex of 25, co-authored 39 publications receiving 2327 citations. Previous affiliations of Kimie Fujita include Shiga University of Medical Science.
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Journal ArticleDOI
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population
Tomomitsu Hirota,Atsushi Takahashi,Michiaki Kubo,Tatsuhiko Tsunoda,Kaori Tomita,Satoru Doi,Kimie Fujita,Akihiko Miyatake,Tadao Enomoto,Takehiko Miyagawa,Mitsuru Adachi,Hiroshi Tanaka,Akio Niimi,Hisako Matsumoto,Isao Ito,Hironori Masuko,Tohru Sakamoto,Nobuyuki Hizawa,Masami Taniguchi,John J. Lima,Charles G. Irvin,Stephen P. Peters,Blanca E. Himes,Augusto A. Litonjua,Kelan G. Tantisira,Scott T. Weiss,Naoyuki Kamatani,Yusuke Nakamura,Mayumi Tamari +28 more
TL;DR: The most significant association with adult asthma is observed at rs404860 in the major histocompatiblity complex region, which is close to rs2070600, a SNP previously reported for association with FEV1/FVC in genome-wide association studies for lung function.
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Thymic Stromal Lymphopoietin Gene Promoter Polymorphisms Are Associated with Susceptibility to Bronchial Asthma
Michishige Harada,Tomomitsu Hirota,Aya I. Jodo,Yuki Hitomi,Masafumi Sakashita,Tatsuhiko Tsunoda,Takehiko Miyagawa,Satoru Doi,Makoto Kameda,Kimie Fujita,Akihiko Miyatake,Tadao Enomoto,Emiko Noguchi,Hironori Masuko,Tohru Sakamoto,Nobuyuki Hizawa,Yoichi Suzuki,Shigemi Yoshihara,Mitsuru Adachi,Motohiro Ebisawa,Hirohisa Saito,Kenji Matsumoto,Toshiharu Nakajima,Rasika A. Mathias,Nicholas Rafaels,Kathleen C. Barnes,Blanca E. Himes,Qing Ling Duan,Kelan G. Tantisira,Scott T. Weiss,Yusuke Nakamura,Steven F. Ziegler,Mayumi Tamari +32 more
TL;DR: The promoter polymorphisms rs3806933 and rs2289276 were significantly associated with disease susceptibility in both childhood atopic and adult asthma, and TSLP variants may serve as a therapeutic target molecule for combination therapy.
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消化器内科外来におけるhospital anxiety and depression scale(HAD尺度)日本語版の信頼性と妥当性の検討
A Higashi,H Yashiro,K Kiyota,Hideto Inokuchi,H Hatta,Kimie Fujita,Yoshiyuki Watanabe,Keiichi Kawai +7 more
TL;DR: It is suggested that the use of the Japanese version of the hospital anxiety and depression scale (HAD) to general hospital outpatients clinic would facilitate detecting emotional disorders in outpat patients.
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Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma.
Yuki Hitomi,Motohiro Ebisawa,Morimitsu Tomikawa,Takanori Imai,Takatsugu Komata,Tomomitsu Hirota,Michishige Harada,Masafumi Sakashita,Yoichi Suzuki,Naoki Shimojo,Yoichi Kohno,Kimie Fujita,Akihiko Miyatake,Satoru Doi,Tadao Enomoto,Masami Taniguchi,Noritaka Higashi,Yusuke Nakamura,Mayumi Tamari +18 more
TL;DR: The results indicate that the NLRP3 SNPs might play an important role in the development of food-induced anaphylaxis and AIA in a gain-of-function manner.
Journal ArticleDOI
Functional analysis of the thymic stromal lymphopoietin variants in human bronchial epithelial cells.
Michishige Harada,Tomomitsu Hirota,Aya I. Jodo,Satoru Doi,Makoto Kameda,Kimie Fujita,Akihiko Miyatake,Tadao Enomoto,Emiko Noguchi,Shigemi Yoshihara,Motohiro Ebisawa,Hirohisa Saito,Kenji Matsumoto,Yusuke Nakamura,Steven F. Ziegler,Mayumi Tamari +15 more
TL;DR: Functional genetic polymorphism of the T SLP gene appears to contribute to Th2-polarized immunity through higher TSLP production by bronchial epithelial cells in response to viral respiratory infections.