T
Tohru Sakamoto
Researcher at University of Tsukuba
Publications - 92
Citations - 3858
Tohru Sakamoto is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 29, co-authored 87 publications receiving 3535 citations.
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Journal ArticleDOI
Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer
Shinsuke Homma,Yukio Ishii,Yuko Morishima,Tadahiro Yamadori,Yosuke Matsuno,Norihiro Haraguchi,Norihiro Kikuchi,Hiroaki Satoh,Tohru Sakamoto,Nobuyuki Hizawa,Ken Itoh,Masayuki Yamamoto +11 more
TL;DR: The results indicate that the Nrf2 system is essential for both cancer cell proliferation and resistance to anticancer drugs and might be a potential target to enhance the effect of anticancers drugs.
Journal ArticleDOI
Nrf2‐deficient mice are highly susceptible to cigarette smoke‐induced emphysema
Takashi Iizuka,Yukio Ishii,Ken Itoh,Takumi Kiwamoto,Toru Kimura,Yosuke Matsuno,Yuko Morishima,Ahmed E. Hegab,Shinsuke Homma,Akihiro Nomura,Tohru Sakamoto,Masako Shimura,Aruto Yoshida,Masayuki Yamamoto,Kiyohisa Sekizawa +14 more
TL;DR: Results indicate that Nrf2 protects against the development of emphysema by regulating not only the oxidant/anti‐oxidant balance, but also inflammation and the protease/anti-protease balance.
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Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population
Tomomitsu Hirota,Atsushi Takahashi,Michiaki Kubo,Tatsuhiko Tsunoda,Kaori Tomita,Satoru Doi,Kimie Fujita,Akihiko Miyatake,Tadao Enomoto,Takehiko Miyagawa,Mitsuru Adachi,Hiroshi Tanaka,Akio Niimi,Hisako Matsumoto,Isao Ito,Hironori Masuko,Tohru Sakamoto,Nobuyuki Hizawa,Masami Taniguchi,John J. Lima,Charles G. Irvin,Stephen P. Peters,Blanca E. Himes,Augusto A. Litonjua,Kelan G. Tantisira,Scott T. Weiss,Naoyuki Kamatani,Yusuke Nakamura,Mayumi Tamari +28 more
TL;DR: The most significant association with adult asthma is observed at rs404860 in the major histocompatiblity complex region, which is close to rs2070600, a SNP previously reported for association with FEV1/FVC in genome-wide association studies for lung function.
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Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population
Tomomitsu Hirota,Atsushi Takahashi,Michiaki Kubo,Tatsuhiko Tsunoda,Kaori Tomita,Masafumi Sakashita,Takechiyo Yamada,Shigeharu Fujieda,Shota Tanaka,Satoru Doi,Akihiko Miyatake,Tadao Enomoto,Chiharu Nishiyama,Nobuhiro Nakano,Keiko Maeda,Ko Okumura,Hideoki Ogawa,Shigaku Ikeda,Emiko Noguchi,Tohru Sakamoto,Nobuyuki Hizawa,Koji Ebe,Hidehisa Saeki,Takashi Sasaki,Tamotsu Ebihara,Masayuki Amagai,Satoshi Takeuchi,Masutaka Furue,Yusuke Nakamura,Mayumi Tamari +29 more
TL;DR: The findings advance the understanding of the genetic basis of atopic dermatitis and replicate the associations of the FLG, C11orf30, TMEM232-SLC25A46, TNFRSF6B-ZGPAT, OVOL1, ACTL9 and KIF3A-IL13 loci that were previously reported in GWAS of European and Chinese individuals.
Journal ArticleDOI
Transcription Factor Nrf2 Plays a Pivotal Role in Protection against Elastase-Induced Pulmonary Inflammation and Emphysema
Yukio Ishii,Ken Itoh,Yuko Morishima,Toru Kimura,Takumi Kiwamoto,Takashi Iizuka,Ahmed E. Hegab,Tomonori Hosoya,Akihiro Nomura,Tohru Sakamoto,Masayuki Yamamoto,Kiyohisa Sekizawa +11 more
TL;DR: It was found that elastase-provoked emphysema was markedly exacerbated in Nrf2-knockout (KO) mice compared with wild-type mice and this improvement correlated well with the appearance of macrophages expressing NRF2-regulated antiprotease and antioxidant genes.