J
John J. Lima
Researcher at Nemours Foundation
Publications - 138
Citations - 5639
John J. Lima is an academic researcher from Nemours Foundation. The author has contributed to research in topics: Asthma & Montelukast. The author has an hindex of 38, co-authored 138 publications receiving 4923 citations. Previous affiliations of John J. Lima include Ohio State University & University of Florida Health Science Center.
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Journal ArticleDOI
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population
Tomomitsu Hirota,Atsushi Takahashi,Michiaki Kubo,Tatsuhiko Tsunoda,Kaori Tomita,Satoru Doi,Kimie Fujita,Akihiko Miyatake,Tadao Enomoto,Takehiko Miyagawa,Mitsuru Adachi,Hiroshi Tanaka,Akio Niimi,Hisako Matsumoto,Isao Ito,Hironori Masuko,Tohru Sakamoto,Nobuyuki Hizawa,Masami Taniguchi,John J. Lima,Charles G. Irvin,Stephen P. Peters,Blanca E. Himes,Augusto A. Litonjua,Kelan G. Tantisira,Scott T. Weiss,Naoyuki Kamatani,Yusuke Nakamura,Mayumi Tamari +28 more
TL;DR: The most significant association with adult asthma is observed at rs404860 in the major histocompatiblity complex region, which is close to rs2070600, a SNP previously reported for association with FEV1/FVC in genome-wide association studies for lung function.
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Impact of genetic polymorphisms of the β2-adrenergic receptor on albuterol bronchodilator pharmacodynamics
John J. Lima,Donald B. Thomason,Mohamad H.N. Mohamed,Louis V. Eberle,Timothy H. Self,Julie A. Johnson +5 more
TL;DR: To determine whether genetic polymorphisms of the β2‐adrenergic receptor gene affect the relationship between albuterol (INN, salbutamol) plasma concentrations and the forced expiratory volume in 1 second (FEV1) in subjects with moderate asthma, a genome-wide study is conducted.
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Asthma in the Elderly: Current Understanding and Future Research Needs: A Report of a National Institute on Aging (NIA) Workshop
Nicola A. Hanania,Monroe J. King,Sidney S. Braman,Carol A. Saltoun,Robert A. Wise,Paul L. Enright,Ann R. Falsey,Sameer K. Mathur,Joe W. Ramsdell,Linda Rogers,D. Stempel,John J. Lima,James E. Fish,Sandra R. Wilson,Cynthia M. Boyd,Kushang V. Patel,Charles G. Irvin,Barbara P. Yawn,Ethan A. Halm,Stephen I. Wasserman,Mark F. Sands,William B. Ershler,Dennis K. Ledford +22 more
TL;DR: The National Institute on Aging convened this workshop to identify what is known and what gaps in knowledge remain and suggest research directions needed to improve the understanding and care of asthma in the elderly.
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Lansoprazole for children with poorly controlled asthma: a randomized controlled trial.
Janet T. Holbrook,Robert A. Wise,Gold Bd,Kathryn V. Blake,Ellen D. Brown,Mario Castro,Allen J. Dozor,John J. Lima,John G. Mastronarde,Marianna Sockrider,W. G. Teague +10 more
TL;DR: In this trial of children with poorly controlled asthma without symptoms of GER who were using inhaled corticosteroids, the addition of lansoprazole, compared with placebo, improved neither symptoms nor lung function but was associated with increased adverse events.
Journal ArticleDOI
Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response.
TL;DR: It is suggested that the genetics of SLCO2B1 may be an important variable in determining the pharmacokinetics and the pharmacodynamics of montelukast.