K
Kiren Ubhi
Researcher at University of California, San Diego
Publications - 39
Citations - 2593
Kiren Ubhi is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Alpha-synuclein & Neurotrophic factors. The author has an hindex of 24, co-authored 39 publications receiving 2295 citations. Previous affiliations of Kiren Ubhi include University of California, Berkeley.
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Journal ArticleDOI
Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
Eliezer Masliah,Edward Rockenstein,Michael Mante,Leslie Crews,Brian Spencer,Anthony Adame,Christina Patrick,Margarita Trejo,Kiren Ubhi,Troy T. Rohn,Sarah Mueller-Steiner,Peter Seubert,Robin Barbour,Lisa McConlogue,Manuel Buttini,Dora Games,Dale Schenk +16 more
TL;DR: 9E4 was effective at reducing behavioral deficits in the water maze and immunization with 9E4 reduced the accumulation of calpain-cleaved α-syn in axons and synapses and the associated neurodegenerative deficits, suggesting that passive immunizations with monoclonal antibodies may be of therapeutic relevance in patients with PD and DLB.
Journal ArticleDOI
Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.
Dora Games,Elvira Valera,Brian Spencer,Edward Rockenstein,Michael Mante,Anthony Adame,Christina Patrick,Kiren Ubhi,Silke Nuber,Patricia Sacayon,Wagner Zago,Peter Seubert,Robin Barbour,Dale Schenk,Eliezer Masliah +14 more
TL;DR: It is demonstrated that antibodies against the CT of α-syn reduce levels of CT-truncated fragments of the protein and its propagation, thus ameliorating PD-like pathology and improving behavioral and motor functions in a mouse model of this disease.
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Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo.
Edward Rockenstein,Silke Nuber,Cassia R. Overk,Kiren Ubhi,Michael Mante,Christina Patrick,Anthony Adame,Margarita Trejo-Morales,Juan Gerez,Paola Picotti,Poul Henning Jensen,Silvia Campioni,Roland Riek,Jürgen Winkler,Fred H. Gage,Beate Winner,Eliezer Masliah +16 more
TL;DR: The hypothesis that accumulating oligomeric α-synuclein may mediate early synaptic pathology in Parkinson's disease and dementia with Lewy bodies by disrupting synaptic vesicles is supported.
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Progressive accumulation of amyloid‐β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
Emiley Pham,Leslie Crews,Kiren Ubhi,Lawrence A. Hansen,Anthony Adame,Anna Cartier,David P. Salmon,Douglas Galasko,Sarah Michael,Jeffrey N. Savas,John R. Yates,Charles G. Glabe,Eliezer Masliah +12 more
TL;DR: In this article, postmortem frontal cortex samples from controls and patients with Alzheimer's disease were fractionated and analyzed for levels of oligomers and synaptic proteins, and the strongest associations were found with amyloid-beta dimers and pentamers.
Journal ArticleDOI
Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors
Kiren Ubhi,Edward Rockenstein,Michael Mante,Chandra Inglis,Anthony Adame,Christina Patrick,Kristen Whitney,Eliezer Masliah +7 more
TL;DR: Analysis of GDNF expression levels in human MSA samples demonstrated a decrease in the white frontal cortex and to a lesser degree in the cerebellum compared with controls, suggesting a mechanism in which αsyn expression in oligodendrocytes impacts on the trophic support provided by these cells for neurons, perhaps contributing to neurodegeneration.