Chunying Yang

TL;DR: It is reported that Puma is essential for hematopoietic cell death triggered by ionizing radiation, deregulated c-Myc expression, and cytokine withdrawal, and required for IR-induced death throughout the developing nervous system and accounts for nearly all of the apoptotic activity attributed to p53 under these conditions.

TL;DR: It is reported that drugs that disrupt the autophagy pathway dramatically augment the antineoplastic effects of SAHA in CML cell lines and primary CML cells expressing wild-type and imatinib-resistant mutant forms of Bcr-Abl, including T315I.

TL;DR: This paper showed that myc oncoproteins induce genes driving aerobic glycolysis, including lactate dehydrogenase-A that generates lactate, and that elevated MCT1 levels are manifest in premalignant and neoplastic Eμ-Myc transgenic B cells and in human malignancies with myc or MYCN involvement.

TL;DR: In this paper, the Ornithine decarboxylase (Odc) inhibitor was used to disable Myc-induced suppression of the Cdk inhibitors p21(Cip1) and p27(Kip1), thereby impairing Myc's proliferative but not apoptotic response.

TL;DR: It is demonstrated that Puma deletion in the E μ-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that ∼75% of Eμ- myc lymphomas naturally select against Puma protein expression, establishing that PUMA is silenced in human malignancies.