K
Kristin Beaudry
Researcher at Beth Israel Deaconess Medical Center
Publications - 15
Citations - 2665
Kristin Beaudry is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Simian immunodeficiency virus & Virus. The author has an hindex of 14, co-authored 15 publications receiving 2646 citations.
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Journal ArticleDOI
Control of Viremia and Prevention of Clinical AIDS in Rhesus Monkeys by Cytokine-Augmented DNA Vaccination
Dan H. Barouch,Sampa Santra,Jörn E. Schmitz,Marcelo J. Kuroda,Tong-Ming Fu,Wendeline Wagner,Miroslawa Bilska,Abie Craiu,Xin Xiao Zheng,Georgia R. Krivulka,Kristin Beaudry,Michelle A. Lifton,Christine E. Nickerson,Wendy L. Trigona,Kara Punt,Dan C. Freed,Liming Guan,Sheri Dubey,Danilo R. Casimiro,Adam J. Simon,Mary-Ellen Davies,Michael Chastain,Terry B. Strom,Rebecca Gelman,David C. Montefiori,Mark G. Lewis,Emilio A. Emini,John W. Shiver,Norman L. Letvin +28 more
TL;DR: The protective efficacy of vaccine-elicited immune responses against a pathogenic SHIV-89.6P challenge in rhesus monkeys is reported, with no evidence of clinical disease or mortality after challenge.
Journal ArticleDOI
Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes
Dan H. Barouch,Jennifer Kunstman,Marcelo J. Kuroda,Jörn E. Schmitz,Sampa Santra,Fred W. Peyerl,Georgia R. Krivulka,Kristin Beaudry,Michelle A. Lifton,Darci A. Gorgone,David C. Montefiori,Mark G. Lewis,Steven M. Wolinsky,Norman L. Letvin +13 more
TL;DR: Viral escape from CTL recognition may be a major limitation of the CTL-based AIDS vaccines that are likely to be administered to large human populations over the next several years.
Journal ArticleDOI
Viral Escape from Dominant Simian Immunodeficiency Virus Epitope-Specific Cytotoxic T Lymphocytes in DNA-Vaccinated Rhesus Monkeys
Dan H. Barouch,Jennifer Kunstman,Jennifer Glowczwskie,Kevin J. Kunstman,Michael A. Egan,Fred W. Peyerl,Sampa Santra,Marcelo J. Kuroda,Jörn E. Schmitz,Kristin Beaudry,Georgia R. Krivulka,Michelle A. Lifton,Darci A. Gorgone,Steven M. Wolinsky,Norman L. Letvin +14 more
TL;DR: The high frequency and pattern of viral escape from dominant epitope-specific CTL in SIV gag DNA-vaccinated rhesus monkeys following a heterologous simian immunodeficiency virus (SIV) challenge suggest that CTL exert selective pressure on viral replication and that viral Escape from CTL may be a limitation of CTL-based AIDS vaccine strategies.
Journal ArticleDOI
Multiclade Human Immunodeficiency Virus Type 1 Envelope Immunogens Elicit Broad Cellular and Humoral Immunity in Rhesus Monkeys
Michael S. Seaman,Ling Xu,Kristin Beaudry,Kristi L. Martin,Margaret H. Beddall,Ayako Miura,Anna Sambor,Bimal K. Chakrabarti,Yue Huang,Robert T. Bailer,Richard A. Koup,John R. Mascola,Gary J. Nabel,Norman L. Letvin,Norman L. Letvin +14 more
TL;DR: It is demonstrated that it is possible to generate protective immune responses by vaccination with genetically diverse isolates of HIV-1 and suggested that a multicomponent vaccine encoding Env proteins from multiple clades of HIV -1 can generate broad Env-specific T-lymphocyte and antibody responses without antigenic interference.
Journal ArticleDOI
Replication-Defective Adenovirus Serotype 5 Vectors Elicit Durable Cellular and Humoral Immune Responses in Nonhuman Primates
Sampa Santra,Michael S. Seaman,Ling Xu,Dan H. Barouch,Carol I. Lord,Michelle A. Lifton,Darci A. Gorgone,Kristin Beaudry,Krisha Svehla,Brent Welcher,Bimal K. Chakrabarti,Yue Huang,Zhi Yong Yang,John R. Mascola,Gary J. Nabel,Norman L. Letvin,Norman L. Letvin +16 more
TL;DR: Administration of ADV5-based vectors in DNA-primed subjects may be a preferred use of this vaccine modality for generating long-term immune protection.