L
L. A. Reed
Researcher at University of Pennsylvania
Publications - 3
Citations - 3588
L. A. Reed is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Frontotemporal dementia and parkinsonism linked to chromosome 17 & Tauopathy. The author has an hindex of 3, co-authored 3 publications receiving 3413 citations. Previous affiliations of L. A. Reed include University of Iowa Hospitals and Clinics.
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Journal ArticleDOI
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Mike Hutton,Corinne Lendon,Patrizia Rizzu,Matt Baker,Susanne Froelich,Susanne Froelich,Henry Houlden,Stuart Pickering-Brown,Sumitra Chakraverty,Adrian M. Isaacs,Andrew Grover,J. Hackett,Jennifer Adamson,Sarah Lincoln,Dennis W. Dickson,Peter Davies,Ronald C. Petersen,M. Stevens,E. De Graaff,E. Wauters,J. Van Baren,M. Hillebrand,Marijke Joosse,J. M. Kwon,Petra Nowotny,Lien Kuei Che,Joanne Norton,John C. Morris,L. A. Reed,John Q. Trojanowski,Hans Basun,Lars Lannfelt,M. Neystat,Stanley Fahn,Frances Dark,Tony Tannenberg,Peter R. Dodd,Nicholas K. Hayward,John B.J. Kwok,Peter R. Schofield,Athena Andreadis,Julie S. Snowden,David Craufurd,David Neary,F. Owen,Ben A. Oostra,John Hardy,Alison Goate,J. C. van Swieten,David M. A. Mann,Timothy Lynch,Peter Heutink +51 more
TL;DR: In this paper, the authors sequenced tau in FTDP-17 families and identified three missense mutations (G272V, P301L and R406W) and three mutations in the 5' splice site of exon in
Journal ArticleDOI
The neuropathology of a chromosome 17-linked autosomal dominant parkinsonism and dementia ("pallido-ponto-nigral degeneration").
L. A. Reed,L. A. Reed,Marie L. Schmidt,Zbigniew K. Wszolek,Brian J. Balin,Virawudh Soontornniyomkij,Virginia M.-Y. Lee,John Q. Trojanowski,R. L. Schelper,R. L. Schelper +9 more
TL;DR: It is concluded that pallido-ponto-nigral degeneration is a hereditary neurodegenerative disorder characterized by neuronal and glial tau-rich inclusions formed from aggregated filaments and hyperphosphorylated tau proteins and can be subcategorized into the tauopathy group of chromosome 17-linked neurodegenersative disorders.
Journal ArticleDOI
Giant cell arteritis in association with cerebral amyloid angiopathy: Immunohistochemical and molecular studies
Karl H. Anders,Zhen Zhen Wang,Mario Kornfeld,Françoise Gray,Virawudh Soontornniyomkij,L. A. Reed,Michael N. Hart,Michael Menchine,Diana Lenard Secor,Harry V. Vinters +9 more
TL;DR: The GCA seen in these cases of CAA most likely represents a foreign body response to amyloid proteins, causing secondary destruction of the vessel wall, and anti-smooth muscle actin immunohistochemistry suggests the occurrence of medial destruction by amyloids, with relative preservation of intimal cells.