L
László Vígh
Researcher at Hungarian Academy of Sciences
Publications - 206
Citations - 11347
László Vígh is an academic researcher from Hungarian Academy of Sciences. The author has contributed to research in topics: Heat shock protein & Membrane fluidity. The author has an hindex of 50, co-authored 195 publications receiving 10343 citations. Previous affiliations of László Vígh include MTA Biological Research Centre & National Institute for Basic Biology, Japan.
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Journal ArticleDOI
Dynamic, yet structured: The cell membrane three decades after the Singer-Nicolson model
György Vereb,János Szöllosi,János Matkó,Péter Nagy,Tibor Farkas,László Vígh,László Mátyus,Thomas A. Waldmann,Sándor Damjanovich +8 more
TL;DR: This work pays tribute to the Singer–Nicolson model, honoring its basic features, “mosaicism” and “diffusion,” which predict the interspersion of proteins and lipids and their ability to undergo dynamic rearrangement via Brownian motion and proposes a new “dynamically structured mosaic model” based on quantitative data.
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HSP72 protects against obesity-induced insulin resistance.
Jason Chung,Anh-Khoi Nguyen,Darren C. Henstridge,Anna G Holmes,Stanley M H Chan,Jose L Mesa,Grame I I Lancaster,Robert J Southgate,Clinton R. Bruce,Stephen J. Duffy,Ibolya Horváth,Ruben Mestril,Matthew J. Watt,Philp L Hooper,Bronwyn A. Kingwell,László Vígh,Andrea L. Hevener,Andrea L. Hevener,Mark A. Febbraio +18 more
TL;DR: An essential role is identified for HSP72 in blocking inflammation and preventing insulin resistance in the context of genetic obesity or high-fat feeding and protection against diet- or obesity-induced hyperglycemia, hyperinsulinemia, glucose intolerance, and insulin resistance.
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Does the membrane's physical state control the expression of heat shock and other genes?
TL;DR: Recent data show that the expression of several genes, particularly those that respond to changes in temperature, ageing or disease, is influenced and/or controlled by the membrane's physical state.
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Heat shock proteins as emerging therapeutic targets.
TL;DR: An overview of the therapeutic approaches is given and some of the key questions of drug development in this novel and promising therapeutic approach are listed.
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Membranes: a meeting point for lipids, proteins and therapies
Pablo V. Escribá,José M. González-Ros,Félix M. Goñi,Paavo K.J. Kinnunen,László Vígh,Lissete Sánchez-Magraner,Asia M. Fernández,Xavier Busquets,Ibolya Horváth,Gwendolyn Barceló-Coblijn +9 more
TL;DR: The role of membrane microdomains and lipid mediators in the control of heat‐shock protein response and stress sensing and signalling and the membrane sensor theory are studied.