L
Laura E. Kuil
Researcher at Erasmus University Rotterdam
Publications - 22
Citations - 511
Laura E. Kuil is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Zebrafish & Microglia. The author has an hindex of 8, co-authored 16 publications receiving 330 citations. Previous affiliations of Laura E. Kuil include Erasmus University Medical Center.
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Journal ArticleDOI
Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia.
Nynke Oosterhof,Irene J. Chang,Ehsan Ghayoor Karimiani,Laura E. Kuil,Dana M. Jensen,Ray A. M. Daza,Erica Young,Lee Astle,Herma C. van der Linde,Giridhar M. Shivaram,Jeroen Demmers,Caitlin S. Latimer,C. Dirk Keene,Emily Loter,Reza Maroofian,Tjakko J. van Ham,Robert F. Hevner,James T. Bennett +17 more
TL;DR: The results suggest that CSF1R is required for human brain development and establish the csf1rDM fish as a model for microgliopathies and exemplify an under-recognized form of phenotypic expansion.
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Colony-Stimulating Factor 1 Receptor (CSF1R) Regulates Microglia Density and Distribution, but Not Microglia Differentiation In Vivo
Nynke Oosterhof,Laura E. Kuil,Herma C. van der Linde,Saskia M. Burm,Woutje M. Berdowski,Wilfred F. J. van IJcken,John C. van Swieten,Elly M. Hol,Mark H. G. Verheijen,Tjakko J. van Ham +9 more
TL;DR: It is found that csf1r mutations led to aberrant microglia density and distribution and regional loss ofMicroglia in zebrafish, which implies that CSF1R mainly regulates microglian density and that early loss ofmicroglia may contribute to ALSP pathogenesis.
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Identification of a Conserved and Acute Neurodegeneration-Specific Microglial Transcriptome in the Zebrafish
Nynke Oosterhof,Inge R. Holtman,Laura E. Kuil,Herma C. van der Linde,Erik Boddeke,Bart J. L. Eggen,Tjakko J. van Ham +6 more
TL;DR: RNA sequencing on microglia acutely isolated from healthy and neurodegenerative zebrafish brains found that a large fraction of the mouse microglial signature is conserved in the zebra Fish, corroborating the use of zebra fish to help understand microglian genetics in mammals and offering opportunities to facilitate functional genetic research on microGlia in vivo in the healthy as well as in the diseased brain.
Journal ArticleDOI
Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain
Laura E. Kuil,Nynke Oosterhof,Nynke Oosterhof,Samuel N. Geurts,Samuel N. Geurts,Herma C. van der Linde,Erik Meijering,Tjakko J. van Ham +7 more
TL;DR: Using a new reverse genetic screening method for zebrafish microglia development, involving automated image analysis, it is identified that il34 facilitates yolk sac macrophage distribution to target organs, including the brain.
Journal ArticleDOI
Gene expression profiling reveals a conserved microglia signature in larval zebrafish.
Julie Mazzolini,Sigrid Le Clerc,Gregoire Morisse,Cédric Coulonges,Laura E. Kuil,Tjakko J. van Ham,Jean-François Zagury,Dirk Sieger +7 more
TL;DR: Results show that larval zebrafish microglia mature rapidly and express the coremicroglia gene signature that seems to be conserved across species.