H
Herma C. van der Linde
Researcher at Erasmus University Rotterdam
Publications - 35
Citations - 2257
Herma C. van der Linde is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Zebrafish & Microglia. The author has an hindex of 18, co-authored 33 publications receiving 1942 citations. Previous affiliations of Herma C. van der Linde include Erasmus University Medical Center.
Papers
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Journal ArticleDOI
Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly.
Laura A. Lettice,Taizo Horikoshi,Simon J. H. Heaney,Marijke J. van Baren,Herma C. van der Linde,Guido J. Breedveld,Marijke Joosse,Nurten A. Akarsu,Ben A. Oostra,Naoto Endo,Minoru Shibata,Mikio Suzuki,Ei-ichi Takahashi,Toshikatsu Shinka,Yutaka Nakahori,Dai Ayusawa,Kazuhiko Nakabayashi,Stephen W. Scherer,Peter Heutink,Robert E. Hill,Sumihare Noji +20 more
TL;DR: A translocation breakpoint in a PPD patient and a transgenic insertion site in the polydactylous mouse mutant sasquatch reveals that the Lmbr1 gene is incidental to the phenotype and that the mutation directly interrupts a cis-acting regulator of Shh, most likely the target for generating PPD mutations in human.
Journal ArticleDOI
Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice.
Femke M.S. de Vrij,Josien Levenga,Herma C. van der Linde,Sebastiaan K. E. Koekkoek,Chris I. De Zeeuw,David L. Nelson,Ben A. Oostra,Rob Willemsen +7 more
TL;DR: A clear defect in prepulse inhibition of startle in Fmr1 KO mice, that could be rescued by MPEP is demonstrated and a structural rescue of Fragile X related protrusion morphology is shown for the first time with two independent mGluR5 antagonists.
Journal ArticleDOI
Mutations in TITF-1 are associated with benign hereditary chorea
Guido J. Breedveld,Jeroen W.F. van Dongen,Cesare Danesino,Andrea Guala,Alan K. Percy,Leon S. Dure,Peter S. Harper,L. P. Lazarou,Herma C. van der Linde,Marijke Joosse,Annette Grüters,Marcy E. MacDonald,Bert B.A. de Vries,Willem F. M. Arts,Ben A. Oostra,Heiko Krude,Peter Heutink +16 more
TL;DR: Evidence is reported that mutations in TITF-1 are associated with BHC, a homeodomain-containing transcription factor essential for the organogenesis of the lung, thyroid and the basal ganglia.
Journal ArticleDOI
Homozygous Mutations in CSF1R Cause a Pediatric-Onset Leukoencephalopathy and Can Result in Congenital Absence of Microglia.
Nynke Oosterhof,Irene J. Chang,Ehsan Ghayoor Karimiani,Laura E. Kuil,Dana M. Jensen,Ray A. M. Daza,Erica Young,Lee Astle,Herma C. van der Linde,Giridhar M. Shivaram,Jeroen Demmers,Caitlin S. Latimer,C. Dirk Keene,Emily Loter,Reza Maroofian,Tjakko J. van Ham,Robert F. Hevner,James T. Bennett +17 more
TL;DR: The results suggest that CSF1R is required for human brain development and establish the csf1rDM fish as a model for microgliopathies and exemplify an under-recognized form of phenotypic expansion.
Journal ArticleDOI
New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics
Henriët Springelkamp,Adriana I Iglesias,Aniket Mishra,Aniket Mishra,René Höhn,Robert Wojciechowski,Anthony P Khawaja,Abhishek Nag,Ya Xing Wang,Jie Jin Wang,Gabriel Cuellar-Partida,Jane Gibson,Jessica N. Cooke Bailey,Eranga N. Vithana,Puya Gharahkhani,Thibaud Boutin,Wishal D. Ramdas,Tanja Zeller,Robert Luben,Ekaterina Yonova-Doing,Ananth C. Viswanathan,Seyhan Yazar,Angela J. Cree,Jonathan L. Haines,Jia Yu Koh,Emmanuelle Souzeau,James F. Wilson,Najaf Amin,Christian P. Müller,Cristina Venturini,Lisa S. Kearns,Jae H. Kang,Yih Chung Tham,Tiger Zhou,Elisabeth M. van Leeuwen,Stefan Nickels,Paul G. Sanfilippo,Paul G. Sanfilippo,Jiemin Liao,Herma C. van der Linde,Wanting Zhao,Leonieke M E van Koolwijk,Li Zheng,Fernando Rivadeneira,Mani Baskaran,Sven J. van der Lee,Shamira A. Perera,Paulus T. V. M. de Jong,Ben A. Oostra,André G. Uitterlinden,Qiao Fan,Albert Hofman,E. Shyong Tai,Johannes R. Vingerling,Xueling Sim,Roger C. W. Wolfs,Yik Ying Teo,Hans G Lemij,Chiea Chuen Khor,Rob Willemsen,Karl J. Lackner,Tin Aung,Nomdo M. Jansonius,Grant W. Montgomery,Philipp S. Wild,Terri L. Young,Kathryn P. Burdon,Pirro G. Hysi,Louis R. Pasquale,Louis R. Pasquale,Tien Yin Wong,Caroline C W Klaver,Alex W. Hewitt,Alex W. Hewitt,Jost B. Jonas,Paul Mitchell,Andrew J. Lotery,Paul J. Foster,Veronique Vitart,Norbert Pfeiffer,Jamie E Craig,David A. Mackey,David A. Mackey,Christopher J Hammond,Janey L. Wiggs,Ching-Yu Cheng,Cornelia M. van Duijn,Stuart MacGregor +87 more
TL;DR: Several novel genes influencing the major clinical risk predictors of POAG are identified and it is shown that genetic variation in CDKN1A is important in POAG risk.