L
Laura J. Duggan
Researcher at Wistar Institute
Publications - 6
Citations - 3274
Laura J. Duggan is an academic researcher from Wistar Institute. The author has contributed to research in topics: Histone & Nucleosome. The author has an hindex of 6, co-authored 6 publications receiving 3156 citations.
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Journal ArticleDOI
Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex.
Patrick A. Grant,Laura J. Duggan,Jacques Côté,S M Roberts,James E. Brownell,Reyes Candau,Reiko Ohba,Tom Owen-Hughes,C D Allis,Fred Winston,Shelley L. Berger,Jerry L. Workman +11 more
TL;DR: The function of Gcn5 as a hist one acetyltransferase within the Ada and SAGA adaptor complexes indicates the importance of histone acetylation during steps in transcription activation mediated by interactions with transcription activators and general transcription factors.
Journal ArticleDOI
Transcriptional activation via sequential histone H2B ubiquitylation and deubiquitylation, mediated by SAGA-associated Ubp8
Karl W. Henry,Anastasia Wyce,Wan Sheng Lo,Laura J. Duggan,N. C. Tolga Emre,Cheng-Fu Kao,Lorraine Pillus,Ali Shilatifard,Mary Ann Osley,Shelley L. Berger +9 more
TL;DR: The results suggest that the histone H2B ubiquitylation state is dynamic during transcription, and that the sequence of histone modifications helps to control transcription.
Journal ArticleDOI
Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14
Wan-Sheng Lo,Raymond C. Trievel,J.R. Rojas,Laura J. Duggan,Jer-Yuan Hsu,C. David Allis,Ronen Marmorstein,Shelley L. Berger +7 more
TL;DR: Observations suggest that transcriptional regulation occurs by multiple mechanistically linked covalent modifications of histones, including serine 10 to alanine in the histone H3 tail.
Journal ArticleDOI
Snf1--a Histone Kinase That Works in Concert with the Histone Acetyltransferase Gcn5 to Regulate Transcription
Wan-Sheng Lo,Laura J. Duggan,N.C.T. Emre,Rimma Belotserkovskya,William S. Lane,Ramin Shiekhattar,Shelley L. Berger +6 more
TL;DR: Results show that Snf1 and the acetyltransferase Gcn5 function in an obligate sequence to enhanceINO1 transcription by modifying histone H3 serine-10 and lysine-14, supporting models of gene regulation wherein transcription is controlled by coordinated patterns of histone modification.
Journal ArticleDOI
Functional Organization of the Yeast SAGA Complex: Distinct Components Involved in Structural Integrity, Nucleosome Acetylation, and TATA-Binding Protein Interaction
David E. Sterner,Patrick A. Grant,S M Roberts,Laura J. Duggan,Rimma Belotserkovskaya,Lisa A. Pacella,Fred Winston,Jerry L. Workman,Shelley L. Berger +8 more
TL;DR: The data demonstrate that SAGA harbors multiple, distinct transcription-related functions, including direct TBP interaction and nucleosomal histone acetylation, which are highly detrimental to growth and transcription.