L
Laura K Fogli
Researcher at New York University
Publications - 11
Citations - 267
Laura K Fogli is an academic researcher from New York University. The author has contributed to research in topics: Romidepsin & T cell. The author has an hindex of 5, co-authored 11 publications receiving 187 citations.
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Journal ArticleDOI
T Cell-Derived IL-17 Mediates Epithelial Changes in the Airway and Drives Pulmonary Neutrophilia
Laura K Fogli,Mark S. Sundrud,Swati Goel,Sofia Bajwa,Kari Jensen,Emmanuel Derudder,Amy Sun,Maryaline Coffre,Catherine Uyttenhove,Jacques Van Snick,Marc Schmidt-Supprian,Anjana Rao,Gabriele Grunig,Joan E. Durbin,Stefano Casola,Klaus Rajewsky,Sergei B. Koralov +16 more
TL;DR: A novel mouse model of spontaneous IL-17–driven lung inflammation that exhibits many similarities to asthma in humans is described and it is found that STAT3 hyperactivity in T lymphocytes causes an expansion of Th17 cells, which home preferentially to the lungs.
Journal ArticleDOI
Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma
Melania H Fanok,Amy Sun,Laura K Fogli,Vijay Narendran,Miriam Eckstein,Kasthuri Kannan,Igor Dolgalev,Charalampos Lazaris,Adriana Heguy,Mary E. Laird,Mark S. Sundrud,Cynthia Liu,Jeff Kutok,Rodrigo S. Lacruz,Jo Ann Latkowski,Iannis Aifantis,Niels Ødum,Kenneth B. Hymes,Kenneth B. Hymes,Swati Goel,Sergei B. Koralov +20 more
TL;DR: Focusing on a key cytokine signaling pathway previously implicated in cutaneous T-cell lymphoma pathogenesis, JAK/STAT signaling, conditional gene targeting is used to develop a fully penetrant small animal model of this disease that recapitulates many key features of mycosis fungoides.
Journal ArticleDOI
The combination of hypomethylating agents and histone deacetylase inhibitors produce marked synergy in preclinical models of T-cell lymphoma.
Enrica Marchi,Kelly Zullo,Jennifer E Amengual,Matko Kalac,Danielle C Bongero,Christine McIntosh,Laura K Fogli,Maura Rossi,Pier Luigi Zinzani,Stefano Pileri,Pier Paolo Piccaluga,Fabio Fuligni,Luigi Scotto,Owen A. O'Connor +13 more
TL;DR: Gene expression array and global methylation profiling revealed differentially expressed genes and modulated pathways for each of the single treatment conditions and the combination, supporting the hypothesis of molecular synergism.
Journal ArticleDOI
Phase II study of atezolizumab in advanced alveolar soft part sarcoma (ASPS).
Abdul Rafeh Naqash,Geraldine O'Sullivan Coyne,Nancy Moore,Elad Sharon,Naoko Takebe,Kristin Fino,Katherine V. Ferry-Galow,James S. Hu,Brian A. Van Tine,Melissa Amber Burgess,William L. Read,Richard F. Riedel,Suzanne George,John Glod,Anthony P. Conley,Jared C. Foster,Laura K Fogli,Ralph E. Parchment,James H. Doroshow,Alice P. Chen +19 more
TL;DR: Preliminary tumor biomarker analysis confirms the presence of multiple PD-1/PD-L1 immune checkpoint (IC) components, indicating that advanced ASPS is an ideal candidate for therapeutic IC inhibition.
Journal ArticleDOI
Augmented Th17 Differentiation Leads to Cutaneous and Synovio-Entheseal Inflammation in a Novel Model of Psoriatic Arthritis.
Lu Yang,Melania H Fanok,Aranzazu Mediero-Munoz,Laura K Fogli,Carmen Corciulo,Shahla Abdollahi,Bruce N. Cronstein,Jose U. Scher,Sergei B. Koralov +8 more
TL;DR: A novel preclinical animal model of psoriatic arthritis (PsA) is introduced in R26Stat3Cstopfl/fl CD4Cre mice, and the role of Th17 cytokines in the disease pathogenesis is investigated.