L
Lauren A. Langford
Researcher at University of Texas MD Anderson Cancer Center
Publications - 45
Citations - 5612
Lauren A. Langford is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: PTEN & Tumor suppressor gene. The author has an hindex of 22, co-authored 45 publications receiving 5363 citations. Previous affiliations of Lauren A. Langford include University of Texas Southwestern Medical Center & Geron Corporation.
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Journal ArticleDOI
Identification of a candidate tumour suppressor gene, MMAC1 , at chromosome 10q23.3 that is mutated in multiple advanced cancers
Peter A. Steck,Mark A. Pershouse,Samar A. Jasser,W. K. A. Yung,Huai Lin,Azra H. Ligon,Lauren A. Langford,Michelle Baumgard,T. Hattier,Thaylon Davis,Cheryl Frye,Rong Hu,Bradley D. Swedlund,David H. F. Teng,Sean V. Tavtigian +14 more
TL;DR: The results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.
Journal Article
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
David H. F. Teng,Rong Hu,Huai Lin,Thaylon Davis,Diana Iliev,Cheryl Frye,Brad Swedlund,Kipp L. Hansen,Vickie L. Vinson,Kathryn L. Gumpper,Lee M. Ellis,Adel K. El-Naggar,Marsha L. Frazier,Samar A. Jasser,Lauren A. Langford,Jeffrey E. Lee,Gordon B. Mills,Mark A. Pershouse,Raphael E. Pollack,Carmen Tornos,Patricia Troncoso,W. K. Alfred Yung,Gregory H. Fujii,Amy E. Berson,Robert Bookstein,Joseph B. Bolen,Scan V. Tavtigian,Peter A. Steck +27 more
TL;DR: The occurrence of inactivating MMAC1 alterations in multiple human cancer types is supported by data supported by the high frequency of 10q allelic loss reported for many cancers.
Journal ArticleDOI
Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype.
Konrad Gabrusiewicz,Benjamin Rodriguez,Jun Wei,Yuuri Hashimoto,Luke M. Healy,Sourindra Maiti,Ginu Thomas,Shouhao Zhou,Qianghu Wang,Ahmed Elakkad,Brandon D. Liebelt,Nasser K. Yaghi,Ravesanker Ezhilarasan,Neal Huang,Jeffrey S. Weinberg,Sujit S. Prabhu,Ganesh Rao,Raymond Sawaya,Lauren A. Langford,Janet M. Bruner,Gregory N. Fuller,Amit Bar-Or,Wei Li,Rivka R. Colen,Michael A. Curran,Krishna P. Bhat,Jack P. Antel,Laurence J.N. Cooper,Erik P. Sulman,Amy B. Heimberger +29 more
TL;DR: G GAM profiling using flow cytometry studies revealed a continuum between the M1- and M2-like phenotype, and contrary to current dogma, GAMs exhibited distinct immunological functions, with the former aligned close to nonpolarized M0 macrophages.
Journal Article
Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.
Tetsuro Sano,Huai Lin,Xiashan Chen,Lauren A. Langford,Dimpy Koul,Melissa L. Bondy,Kenneth R. Hess,Jeffrey N. Myers,Yong Kil Hong,W. K. Alfred Yung,Peter A. Steck +10 more
TL;DR: Altered expression of MMAC/PTEN may play a significant role in the progression of GBM and patient outcome, and Kaplan-Meier survival plots showed a significantly better prognosis for patients whose tumors expressed high levels of the gene.
Journal ArticleDOI
Telomerase activity in human brain tumours.
TL;DR: A distinct subgroup of brain tumour consists of transformed yet pre-immortal cells that follow different pathways of neoplastic progression, according to analysis of telomerase activity in 90 human gliomas.