M
Michelle Baumgard
Researcher at Myriad Genetics
Publications - 5
Citations - 3863
Michelle Baumgard is an academic researcher from Myriad Genetics. The author has contributed to research in topics: Gene & Tumor suppressor gene. The author has an hindex of 5, co-authored 5 publications receiving 3786 citations.
Papers
More filters
Journal ArticleDOI
Identification of a candidate tumour suppressor gene, MMAC1 , at chromosome 10q23.3 that is mutated in multiple advanced cancers
Peter A. Steck,Mark A. Pershouse,Samar A. Jasser,W. K. A. Yung,Huai Lin,Azra H. Ligon,Lauren A. Langford,Michelle Baumgard,T. Hattier,Thaylon Davis,Cheryl Frye,Rong Hu,Bradley D. Swedlund,David H. F. Teng,Sean V. Tavtigian +14 more
TL;DR: The results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.
Journal ArticleDOI
A candidate prostate cancer susceptibility gene at chromosome 17p.
Sean V. Tavtigian,Jacques Simard,David H. F. Teng,Vicki Abtin,Michelle Baumgard,Audrey Beck,Nicola J. Camp,Nicola J. Camp,Arlene Carillo,Yang Chen,Priya Dayananth,Marc Desrochers,Martine Dumont,James M. Farnham,David A. Frank,Cheryl Frye,Siavash Ghaffari,Jamila Gupte,Rong Hu,Diana Iliev,Teresa Janecki,Edward N. Kort,Kirsten Laity,Amber Leavitt,Gilles Leblanc,Jodi Mcarthur-Morrison,Amy Pederson,Brandon Penn,Kelly T. Peterson,Julia Reid,Sam Richards,Marianne Schroeder,Richard D. Smith,Sarah C. Snyder,Brad Swedlund,Jeff Swensen,Alun Thomas,Martine Tranchant,Ann Marie Woodland,Fernand Labrie,Mark H. Skolnick,Susan L. Neuhausen,Johanna M. Rommens,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright +44 more
TL;DR: A genome-wide scan of large, high-risk pedigrees from Utah has provided evidence for linkage to a locus on chromosome 17p, identifying a gene, ELAC2, harboring mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two pedigree.
Journal Article
Human Mitogen-activated Protein Kinase Kinase 4 as a Candidate Tumor Suppressor
David H. F. Teng,William L. Perry,James K. Hogan,Michelle Baumgard,Russell Bell,Simin Berry,Thaylon Davis,David A. Frank,Cheryl Frye,T. Hattier,Rong Hu,Srikanth Jammulapati,Teresa Janecki,Amber Leavitt,J.T. Mitchell,Ralph Pero,David Sexton,Marianne Schroeder,Pi Hsia Su,Brad Swedlund,John M. Kyriakis,Joseph Avruch,Paul L. Bartel,Alexander K. C. Wong,Arnold R. Oliphant,Alun Thomas,Mark H. Skolnick,Sean V. Tavtigian +27 more
TL;DR: Findings suggest that MKK4 may function as a suppressor of tumorigenesis or metastasis in certain types of cells.
Journal ArticleDOI
Low incidence of BRCA2 mutations in breast carcinoma and other cancers.
David H.-R Teng,Robert Bogden,J.T. Mitchell,Michelle Baumgard,Russell Bell,Simin Berry,Thaylon Davis,Phuong C. Ha,Robert Kehrer,Srikanth Jammulapati,Qian Chen,Kenneth Offit,Mark H. Skolnick,Sean V. Tavtigian,Suresh C. Jhanwar,Brad Swedlund,Alexander K. C. Wong,Alexander Kamb +17 more
TL;DR: Surprisingly, mutations in BRCA2 are infrequent in cancers including breast carcinoma, however, a probable germline mutation in a pancreatic tumour cell line suggests a role for BrcA2 in susceptibility to pancreatic cancer.
Journal Article
Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding
Nils Adey,Liwen Huang,Patricia A. Ormonde,Michelle Baumgard,Ralph Pero,Deepthi V. Byreddy,Sean V. Tavtigian,Paul L. Bartel +7 more
TL;DR: Threonine phosphorylation of the MMAC1/ PTEN-PDZBD peptide inhibited both microtiter plate binding to the hDLG and hMAST205 PDZ domains and coprecipitation of the Mr 140,000 and > 200,000 proteins, but promoted coprecIPitation of proteins of approximately Mr 90, thousands and Mr 120,000 from A431 cell lysate.