D
David H. F. Teng
Researcher at Myriad Genetics
Publications - 20
Citations - 5704
David H. F. Teng is an academic researcher from Myriad Genetics. The author has contributed to research in topics: Gene & Tumor suppressor gene. The author has an hindex of 14, co-authored 20 publications receiving 5594 citations.
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Journal ArticleDOI
Identification of a candidate tumour suppressor gene, MMAC1 , at chromosome 10q23.3 that is mutated in multiple advanced cancers
Peter A. Steck,Mark A. Pershouse,Samar A. Jasser,W. K. A. Yung,Huai Lin,Azra H. Ligon,Lauren A. Langford,Michelle Baumgard,T. Hattier,Thaylon Davis,Cheryl Frye,Rong Hu,Bradley D. Swedlund,David H. F. Teng,Sean V. Tavtigian +14 more
TL;DR: The results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.
Journal ArticleDOI
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
Sean V. Tavtigian,Jacques Simard,Johanna M. Rommens,Fergus J. Couch,Donna M Shattuck-Eidens,Susan L. Neuhausen,Sofia D. Merajver,Steinunn Thorlacius,Kenneth Offit,Dominique Stoppa-Lyonnet,Carole Bélanger,Russell Bell,Simin Berry,Robert Bogden,Qian Chen,Thaylon Davis,Martine Dumont,Cheryl Frye,T. Hattier,Srikanth Jammulapati,Teresa Janecki,Ping Jiang,Robert Kehrer,J.-F. Leblanc,J.T. Mitchell,Jodi Mcarthur-Morrison,K. Nguyen,Yi Peng,Chantal Samson,Marianne Schroeder,S.C. Snyder,Linda Steele,M. Stringfellow,C. Stroup,Bradley D. Swedlund,J. Swense,David H. F. Teng,Alun Thomas,T.D. Tran,Martine Tranchant,Jane Weaver-Feldhaus,Alexander K. C. Wong,Hiroaki Shizuya,Jorunn E. Eyfjord,Lisa A. Cannon-Albright,Fernand Labrie,Mark H. Skolnick,Mark H. Skolnick,Barbara L. Weber,Alexander Kamb,David E. Goldgar,David E. Goldgar +51 more
TL;DR: The complete coding sequence and exonic structure of BRCA2 is determined, and its pattern of expression is examined, and a mutational analysis of B RCA2 in families selected on the basis of linkage analysis and/or the presence of one or more cases of male breast cancer is reported.
Journal ArticleDOI
A candidate prostate cancer susceptibility gene at chromosome 17p.
Sean V. Tavtigian,Jacques Simard,David H. F. Teng,Vicki Abtin,Michelle Baumgard,Audrey Beck,Nicola J. Camp,Nicola J. Camp,Arlene Carillo,Yang Chen,Priya Dayananth,Marc Desrochers,Martine Dumont,James M. Farnham,David A. Frank,Cheryl Frye,Siavash Ghaffari,Jamila Gupte,Rong Hu,Diana Iliev,Teresa Janecki,Edward N. Kort,Kirsten Laity,Amber Leavitt,Gilles Leblanc,Jodi Mcarthur-Morrison,Amy Pederson,Brandon Penn,Kelly T. Peterson,Julia Reid,Sam Richards,Marianne Schroeder,Richard D. Smith,Sarah C. Snyder,Brad Swedlund,Jeff Swensen,Alun Thomas,Martine Tranchant,Ann Marie Woodland,Fernand Labrie,Mark H. Skolnick,Susan L. Neuhausen,Johanna M. Rommens,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright +44 more
TL;DR: A genome-wide scan of large, high-risk pedigrees from Utah has provided evidence for linkage to a locus on chromosome 17p, identifying a gene, ELAC2, harboring mutations (including a frameshift and a nonconservative missense change) that segregate with prostate cancer in two pedigree.
Journal Article
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
David H. F. Teng,Rong Hu,Huai Lin,Thaylon Davis,Diana Iliev,Cheryl Frye,Brad Swedlund,Kipp L. Hansen,Vickie L. Vinson,Kathryn L. Gumpper,Lee M. Ellis,Adel K. El-Naggar,Marsha L. Frazier,Samar A. Jasser,Lauren A. Langford,Jeffrey E. Lee,Gordon B. Mills,Mark A. Pershouse,Raphael E. Pollack,Carmen Tornos,Patricia Troncoso,W. K. Alfred Yung,Gregory H. Fujii,Amy E. Berson,Robert Bookstein,Joseph B. Bolen,Scan V. Tavtigian,Peter A. Steck +27 more
TL;DR: The occurrence of inactivating MMAC1 alterations in multiple human cancer types is supported by data supported by the high frequency of 10q allelic loss reported for many cancers.
Journal ArticleDOI
BRCA1 Sequence Analysis in Women at High Risk for Susceptibility Mutations: Risk Factor Analysis and Implications for Genetic Testing
Donna M Shattuck-Eidens,Arnold R. Oliphant,Melody McClure,Celeste McBride,Jamila Gupte,Todd Rubano,Dmitry Pruss,Sean V. Tavtigian,David H. F. Teng,Nils Adey,Mark Staebell,Kathryn Gumpper,Ron Lundstrom,Mark Hulick,Mark Kelly,John Holmen,Beth Lingenfelter,Susan Manley,Frank Fujimura,Michael C. Luce,Brian E. Ward,Lisa A. Cannon-Albright,Linda Steele,Kenneth Offit,Teresa Gilewski,Larry Norton,Karen T. Brown,Charlene Schulz,Heather Hampel,A. Schluger,Elena Giulotto,Wainer Zoli,Alberto Ravaioli,Heli Nevanlinna,Seppo Pyrhonen,Peter T. Rowley,Starlene Loader,Michael P. Osborne,Mary B. Daly,Isidore Tepler,Paul L. Weinstein,Jennifer L. Scalia,Richard Michaelson,Rodney J. Scott,Paolo Radice,Marco A. Pierotti,Judy Garber,Claudine Isaacs,Beth N. Peshkin,Marc E. Lippman,Michael H. Dosik,Maria A. Caligo,Robert M. Greenstein,Robert Pilarski,Barbara L. Weber,Renate Burgemeister,Thomas S. Frank,Mark H. Skolnick,Alun Thomas +58 more
TL;DR: Using logistic regression analysis, this work provides a method for evaluating the probability of a woman's carrying a deleterious BRCA1 mutation for a wide range of cases, which can be an important tool for clinicians as they incorporate genetic susceptibility testing into their medical practice.