T
Thaylon Davis
Researcher at Myriad Genetics
Publications - 7
Citations - 4639
Thaylon Davis is an academic researcher from Myriad Genetics. The author has contributed to research in topics: Tumor suppressor gene & Gene. The author has an hindex of 7, co-authored 7 publications receiving 4544 citations.
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Journal ArticleDOI
Identification of a candidate tumour suppressor gene, MMAC1 , at chromosome 10q23.3 that is mutated in multiple advanced cancers
Peter A. Steck,Mark A. Pershouse,Samar A. Jasser,W. K. A. Yung,Huai Lin,Azra H. Ligon,Lauren A. Langford,Michelle Baumgard,T. Hattier,Thaylon Davis,Cheryl Frye,Rong Hu,Bradley D. Swedlund,David H. F. Teng,Sean V. Tavtigian +14 more
TL;DR: The results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.
Journal ArticleDOI
The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds.
Sean V. Tavtigian,Jacques Simard,Johanna M. Rommens,Fergus J. Couch,Donna M Shattuck-Eidens,Susan L. Neuhausen,Sofia D. Merajver,Steinunn Thorlacius,Kenneth Offit,Dominique Stoppa-Lyonnet,Carole Bélanger,Russell Bell,Simin Berry,Robert Bogden,Qian Chen,Thaylon Davis,Martine Dumont,Cheryl Frye,T. Hattier,Srikanth Jammulapati,Teresa Janecki,Ping Jiang,Robert Kehrer,J.-F. Leblanc,J.T. Mitchell,Jodi Mcarthur-Morrison,K. Nguyen,Yi Peng,Chantal Samson,Marianne Schroeder,S.C. Snyder,Linda Steele,M. Stringfellow,C. Stroup,Bradley D. Swedlund,J. Swense,David H. F. Teng,Alun Thomas,T.D. Tran,Martine Tranchant,Jane Weaver-Feldhaus,Alexander K. C. Wong,Hiroaki Shizuya,Jorunn E. Eyfjord,Lisa A. Cannon-Albright,Fernand Labrie,Mark H. Skolnick,Mark H. Skolnick,Barbara L. Weber,Alexander Kamb,David E. Goldgar,David E. Goldgar +51 more
TL;DR: The complete coding sequence and exonic structure of BRCA2 is determined, and its pattern of expression is examined, and a mutational analysis of B RCA2 in families selected on the basis of linkage analysis and/or the presence of one or more cases of male breast cancer is reported.
Journal Article
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
David H. F. Teng,Rong Hu,Huai Lin,Thaylon Davis,Diana Iliev,Cheryl Frye,Brad Swedlund,Kipp L. Hansen,Vickie L. Vinson,Kathryn L. Gumpper,Lee M. Ellis,Adel K. El-Naggar,Marsha L. Frazier,Samar A. Jasser,Lauren A. Langford,Jeffrey E. Lee,Gordon B. Mills,Mark A. Pershouse,Raphael E. Pollack,Carmen Tornos,Patricia Troncoso,W. K. Alfred Yung,Gregory H. Fujii,Amy E. Berson,Robert Bookstein,Joseph B. Bolen,Scan V. Tavtigian,Peter A. Steck +27 more
TL;DR: The occurrence of inactivating MMAC1 alterations in multiple human cancer types is supported by data supported by the high frequency of 10q allelic loss reported for many cancers.
Journal Article
Human Mitogen-activated Protein Kinase Kinase 4 as a Candidate Tumor Suppressor
David H. F. Teng,William L. Perry,James K. Hogan,Michelle Baumgard,Russell Bell,Simin Berry,Thaylon Davis,David A. Frank,Cheryl Frye,T. Hattier,Rong Hu,Srikanth Jammulapati,Teresa Janecki,Amber Leavitt,J.T. Mitchell,Ralph Pero,David Sexton,Marianne Schroeder,Pi Hsia Su,Brad Swedlund,John M. Kyriakis,Joseph Avruch,Paul L. Bartel,Alexander K. C. Wong,Arnold R. Oliphant,Alun Thomas,Mark H. Skolnick,Sean V. Tavtigian +27 more
TL;DR: Findings suggest that MKK4 may function as a suppressor of tumorigenesis or metastasis in certain types of cells.
Journal ArticleDOI
Low incidence of BRCA2 mutations in breast carcinoma and other cancers.
David H.-R Teng,Robert Bogden,J.T. Mitchell,Michelle Baumgard,Russell Bell,Simin Berry,Thaylon Davis,Phuong C. Ha,Robert Kehrer,Srikanth Jammulapati,Qian Chen,Kenneth Offit,Mark H. Skolnick,Sean V. Tavtigian,Suresh C. Jhanwar,Brad Swedlund,Alexander K. C. Wong,Alexander Kamb +17 more
TL;DR: Surprisingly, mutations in BRCA2 are infrequent in cancers including breast carcinoma, however, a probable germline mutation in a pancreatic tumour cell line suggests a role for BrcA2 in susceptibility to pancreatic cancer.