H
Huai Lin
Researcher at University of Texas MD Anderson Cancer Center
Publications - 8
Citations - 3855
Huai Lin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Loss of heterozygosity & PTEN. The author has an hindex of 8, co-authored 8 publications receiving 3771 citations.
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Journal ArticleDOI
Identification of a candidate tumour suppressor gene, MMAC1 , at chromosome 10q23.3 that is mutated in multiple advanced cancers
Peter A. Steck,Mark A. Pershouse,Samar A. Jasser,W. K. A. Yung,Huai Lin,Azra H. Ligon,Lauren A. Langford,Michelle Baumgard,T. Hattier,Thaylon Davis,Cheryl Frye,Rong Hu,Bradley D. Swedlund,David H. F. Teng,Sean V. Tavtigian +14 more
TL;DR: The results identify a strong candidate tumour suppressor gene at chromosome 10q23.3, whose loss of function appears to be associated with the oncogenesis of multiple human cancers.
Journal Article
MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
David H. F. Teng,Rong Hu,Huai Lin,Thaylon Davis,Diana Iliev,Cheryl Frye,Brad Swedlund,Kipp L. Hansen,Vickie L. Vinson,Kathryn L. Gumpper,Lee M. Ellis,Adel K. El-Naggar,Marsha L. Frazier,Samar A. Jasser,Lauren A. Langford,Jeffrey E. Lee,Gordon B. Mills,Mark A. Pershouse,Raphael E. Pollack,Carmen Tornos,Patricia Troncoso,W. K. Alfred Yung,Gregory H. Fujii,Amy E. Berson,Robert Bookstein,Joseph B. Bolen,Scan V. Tavtigian,Peter A. Steck +27 more
TL;DR: The occurrence of inactivating MMAC1 alterations in multiple human cancer types is supported by data supported by the high frequency of 10q allelic loss reported for many cancers.
Journal Article
Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.
Tetsuro Sano,Huai Lin,Xiashan Chen,Lauren A. Langford,Dimpy Koul,Melissa L. Bondy,Kenneth R. Hess,Jeffrey N. Myers,Yong Kil Hong,W. K. Alfred Yung,Peter A. Steck +10 more
TL;DR: Altered expression of MMAC/PTEN may play a significant role in the progression of GBM and patient outcome, and Kaplan-Meier survival plots showed a significantly better prognosis for patients whose tumors expressed high levels of the gene.
Journal Article
Allelic deletion analyses of MMAC/PTEN and DMBT1 loci in gliomas: relationship to prognostic significance.
Huai Lin,Melissa L. Bondy,Lauren A. Langford,Kenneth R. Hess,George L. Delclos,Xifeng Wu,Wenyaw Chan,Mark A. Pershouse,W. K. Alfred Yung,Peter A. Steck +9 more
TL;DR: The results suggest that the DMBT1 gene may be involved early in the oncogenesis of gliomas, whereas alterations in the MMAC/PTEN gene might be a late event in theOncogenesis related to progression ofgliomas and provide a significant prognostic marker for patient survival.
Journal ArticleDOI
Lipocalin 2 is required for BCR-ABL-induced tumorigenesis
Xiaohong Leng,Huai Lin,Tian Ding,Yu Wang,Yadi Wu,Sherry Klumpp,Tong Sun,Yunli Zhou,P Monaco,John W. Belmont,Alan Aderem,Shizuo Akira,Roland K. Strong,Ralph B. Arlinghaus +13 more
TL;DR: The findings demonstrate that lipocalin 2 has at least two functions related to tumorigenesis, one involving apoptosis induction of normal hematopoietic cells and the other being tissue invasion by leukemia cells.