Chloé Abels

TL;DR: It is shown that circulating monocytes engraft in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells, like embryonic precursors if the niche is available to them.

TL;DR: The data uncover the multifaceted and opposing roles of M-CS FR and GM-CSFR signaling in governing the phenotype of macrophage subsets in tumors, and provide new insight into the mechanism of action underlying M- CSFR blockade.

TL;DR: Ly6C– monocytes can dampen liver damage caused by an extensive Ly6C+ monocyte-associated inflammatory immune response in T. congolense trypanotolerant animals, and may represent a therapeutic approach in liver pathogenicity induced by chronic infection.

TL;DR: It was found that gap junction communication deteriorates upon acetaminophen intoxication in wild type mice, which is associated with a switch in mRNA and protein production from connexin32 andConnexin26 to connexIn43, which suggests that hepatic connex in43-based signaling may protect against acetamophen-induced liver toxicity.

TL;DR: Results indicate that Nbs targeting Vsig4 as molecular imaging biomarker enable non-invasive monitoring of KCs during hepatic inflammation.