L
Lea Marie
Researcher at Columbia University
Publications - 6
Citations - 116
Lea Marie is an academic researcher from Columbia University. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 2, co-authored 3 publications receiving 47 citations. Previous affiliations of Lea Marie include Columbia University Medical Center.
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Journal ArticleDOI
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
Hannah L. Klein,Giedrė Bačinskaja,Jun Che,Anais Cheblal,Rajula Elango,Anastasiya Epshtein,Devon M. Fitzgerald,Belén Gómez-González,Sharik R. Khan,Sandeep Kumar,Bryan A Leland,Lea Marie,Qian Mei,Judith Miné-Hattab,Judith Miné-Hattab,Alicja Piotrowska,Erica J Polleys,Christopher D. Putnam,Christopher D. Putnam,Elina A. Radchenko,Anissia Ait Saada,Anissia Ait Saada,Cynthia J. Sakofsky,Eun Yong Shim,Mathew Stracy,Jun Xia,Zhenxin Yan,Yi Yin,Andrés Aguilera,Juan Lucas Argueso,Catherine H. Freudenreich,Susan M. Gasser,Dmitry A. Gordenin,James E. Haber,Grzegorz Ira,Sue Jinks-Robertson,Megan C. King,Richard D. Kolodner,Andrei Kuzminov,Sarah Lambert,Sarah Lambert,Sang Eun Lee,Kyle M. Miller,Kyle M. Miller,Sergei M. Mirkin,Thomas D. Petes,Susan M. Rosenberg,Rodney Rothstein,Lorraine S. Symington,Pawel Zawadzki,Nayun Kim,Michael Lisby,Anna Malkova +52 more
TL;DR: The most commonly used cellular assays, developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily be manipulated are reviewed, discussed, and presented as the guidelines for future studies.
Journal ArticleDOI
The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination.
Upasana Roy,Youngho Kwon,Lea Marie,Lorraine S. Symington,Patrick Sung,Michael Lisby,Eric C. Greene +6 more
TL;DR: In this article, the authors used single-molecule imaging to reveal that the Rad51 paralog complex Rad55-Rad57 promotes assembly of Rad51 recombinase filament through transient interactions, providing evidence that it acts like a classical molecular chaperone.
Journal ArticleDOI
Mechanism for inverted-repeat recombination induced by a replication fork barrier
Lea Marie,Lorraine S. Symington +1 more
TL;DR: In this paper , the replication fork block stimulates a unique recombination pathway dependent on Rad51 strand invasion and Rad52-Rad59 strand annealing activities, Mph1/Rad5 fork remodelers, Mre11/Exo1/Dna2 resection machineries, Rad1-Rad10 nuclease and DNA polymerase δ.
Journal ArticleDOI
Mechanism for inverted-repeat recombination induced by a replication fork barrier
Lea Marie,Lorraine S. Symington +1 more
TL;DR: In this paper , the replication fork block stimulates a unique recombination pathway dependent on Rad51 strand invasion and Rad52-Rad59 strand annealing activities, Mph1/Rad5 fork remodelers, Mre11/Exo1/Dna2 resection machineries, Rad1-Rad10 nuclease and DNA polymerase δ.
Journal ArticleDOI
Failure of Initial Curative Treatment for Non-Metastatic Anal Squamous Cell Carcinoma: From Prognostic Factors Analysis to Stratified Treatment.
Claire Jaraudias,Lucile Montagneb Angélique Saint,Renaud Schiappa,D. Baron,Lea Marie,Karen Benezery,C. Scouarnec,Eric Francois,Ludovic Evesque +8 more
TL;DR: In this article , the authors describe the patterns of failures of the initial treatment, their subsequent evolution and identify prognostic factors in these relapsed patients, including gender, initial lymph node status, type of failure, response to treatment's failure.