C
Cynthia J. Sakofsky
Researcher at National Institutes of Health
Publications - 18
Citations - 621
Cynthia J. Sakofsky is an academic researcher from National Institutes of Health. The author has contributed to research in topics: DNA replication & Sulfolobus. The author has an hindex of 10, co-authored 16 publications receiving 515 citations. Previous affiliations of Cynthia J. Sakofsky include University of Iowa & Indiana University – Purdue University Indianapolis.
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Journal ArticleDOI
Break-Induced Replication Is a Source of Mutation Clusters Underlying Kataegis
Cynthia J. Sakofsky,Steven A. Roberts,Ewa P. Malc,Piotr A. Mieczkowski,Michael A. Resnick,Dmitry A. Gordenin,Anna Malkova,Anna Malkova +7 more
TL;DR: This article identified double-strand break (DSB)-induced replication (BIR) as another powerful source of mutation clusters that formed in nearly half of wild-type yeast cells undergoing BIR in the presence of alkylating damage.
Journal ArticleDOI
Break induced replication in eukaryotes: mechanisms, functions, and consequences.
Cynthia J. Sakofsky,Anna Malkova +1 more
TL;DR: Significant progress has been made towards understanding microhomology-mediated BIR (MMBIR) that can promote complex chromosomal rearrangements, including those associated with cancer and those leading to a number of neurological disorders in humans.
Break-Induced Replication is a Source of Mutation Clusters Underlying Kataegis
Cynthia J. Sakofsky,Steven A. Roberts,Ewa P. Malc,Piotr A. Mieczkowski,Michael A. Resnick,Dmitry A. Gordenin,Anna Malkova,Anna Malkova +7 more
TL;DR: Double-strand break-induced replication (BIR) is identified as another powerful source of mutation clusters that formed in nearly half of wild-type yeast cells undergoing BIR in the presence of alkylating damage, and these features closely resemble kataegic events in cancers.
Journal ArticleDOI
Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways
Hannah L. Klein,Giedrė Bačinskaja,Jun Che,Anais Cheblal,Rajula Elango,Anastasiya Epshtein,Devon M. Fitzgerald,Belén Gómez-González,Sharik R. Khan,Sandeep Kumar,Bryan A Leland,Lea Marie,Qian Mei,Judith Miné-Hattab,Judith Miné-Hattab,Alicja Piotrowska,Erica J Polleys,Christopher D. Putnam,Christopher D. Putnam,Elina A. Radchenko,Anissia Ait Saada,Anissia Ait Saada,Cynthia J. Sakofsky,Eun Yong Shim,Mathew Stracy,Jun Xia,Zhenxin Yan,Yi Yin,Andrés Aguilera,Juan Lucas Argueso,Catherine H. Freudenreich,Susan M. Gasser,Dmitry A. Gordenin,James E. Haber,Grzegorz Ira,Sue Jinks-Robertson,Megan C. King,Richard D. Kolodner,Andrei Kuzminov,Sarah Lambert,Sarah Lambert,Sang Eun Lee,Kyle M. Miller,Kyle M. Miller,Sergei M. Mirkin,Thomas D. Petes,Susan M. Rosenberg,Rodney Rothstein,Lorraine S. Symington,Pawel Zawadzki,Nayun Kim,Michael Lisby,Anna Malkova +52 more
TL;DR: The most commonly used cellular assays, developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily be manipulated are reviewed, discussed, and presented as the guidelines for future studies.
Journal ArticleDOI
Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.
Cynthia J. Sakofsky,Natalie Saini,Leszek J. Klimczak,Kin Chan,Ewa P. Malc,Piotr A. Mieczkowski,Adam B. Burkholder,David C. Fargo,Dmitry A. Gordenin +8 more
TL;DR: It is shown that ssDNA intermediates formed during the repair of gamma-induced bursts of double-strand breaks (DSBs) in the presence of APOBEC3A in yeast lead to multiple APOBec-induced clusters similar to cancer.