L
Leanne Barker
Researcher at University of Oxford
Publications - 24
Citations - 635
Leanne Barker is an academic researcher from University of Oxford. The author has contributed to research in topics: Antibiotic resistance & Nanopore sequencing. The author has an hindex of 6, co-authored 21 publications receiving 334 citations. Previous affiliations of Leanne Barker include John Radcliffe Hospital & Liverpool School of Tropical Medicine.
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Journal ArticleDOI
Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018
David W Eyre,Nicholas D Sanderson,Emily Lord,Natasha Regisford-Reimmer,Kevin K Chau,Leanne Barker,Markus Morgan,Robert Newnham,Daniel Golparian,Magnus Unemo,Derrick W. Crook,Derrick W. Crook,Derrick W. Crook,Tim E. A. Peto,Tim E. A. Peto,Gwenda Hughes,Michelle J Cole,Helen Fifer,Anne Edwards,Monique Andersson +19 more
TL;DR: A heterosexual male was diagnosed with gonorrhoea in the United Kingdom following sexual intercourse with a locally resident female in Thailand and failed treatment with ceftriaxone plus doxycycline and subsequently spectinomycin, resulting in resistance arose from two mechanisms combining for the first time in a genetic background similar to a commonly circulating strain.
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Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018
David W Eyre,Katy Town,Teresa L Street,Leanne Barker,Nicholas D Sanderson,Michelle J Cole,Hamish Mohammed,Rachel Pitt,Maya Gobin,Charles Irish,Daniel Gardiner,James Sedgwick,Charles R. Beck,John Saunders,Deborah Turbitt,Clare Cook,Nick Phin,Bavithra Nathan,Paddy Horner,Helen Fifer +19 more
TL;DR: In this article, the authors describe detection in the United Kingdom (UK) of the drug-resistant Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate azithromycin resistance.
Journal ArticleDOI
Panton-Valentine leucocidin is the key determinant of Staphylococcus aureus pyomyositis in a bacterial GWAS
Bernadette C. Young,Sarah G Earle,Sona Soeng,Poda Sar,Varun Kumar,Songly Hor,Vuthy Sar,Rachel Bousfield,Nicholas D Sanderson,Leanne Barker,Nicole Stoesser,Katherine R. W. Emary,Christopher M. Parry,Christopher M. Parry,Emma K. Nickerson,Paul Turner,Paul Turner,Rory Bowden,Derrick W. Crook,David H. Wyllie,David H. Wyllie,Nicholas P. J. Day,Daniel J. Wilson,Daniel J. Wilson,Catrin E. Moore,Catrin E. Moore +25 more
TL;DR: Staphylococcal pyomyositis, like tetanus and diphtheria, is established as critically dependent on a single toxin and the potential for association studies to identify specific bacterial genes promoting severe human disease is demonstrated.
Journal ArticleDOI
Optimizing DNA Extraction Methods for Nanopore Sequencing of Neisseria gonorrhoeae Directly from Urine Samples.
Teresa L Street,Leanne Barker,Nicholas D Sanderson,James Kavanagh,Sarah Hoosdally,Kevin Cole,Robert Newnham,Mathyruban Selvaratnam,Monique Andersson,Martin J. Llewelyn,Justin O'Grady,Derrick W. Crook,Derrick W. Crook,David W Eyre,David W Eyre,David W Eyre +15 more
TL;DR: Using Nanopore sequencing of urine samples from men with urethral gonorrhea, sufficient data can be obtained to reconstruct whole genomes in the majority of samples without the need for culture, and sequencing of the large majority of the genome was frequently achieved.
Journal ArticleDOI
Niche and local geography shape the pangenome of wastewater- and livestock-associated Enterobacteriaceae.
Liam P. Shaw,Kevin K Chau,James Kavanagh,Manal AbuOun,Emma Stubberfield,H. Soon Gweon,Leanne Barker,Gillian Rodger,Michael J. Bowes,Alasdair T. M. Hubbard,Alasdair T. M. Hubbard,H Pickford,Jeremy Swann,Jeremy Swann,Daniel Gilson,Richard P. Smith,Sarah Hoosdally,Robert Sebra,Robert Sebra,Howard Brett,Tim E. A. Peto,Tim E. A. Peto,Mark J. Bailey,Derrick W. Crook,Derrick W. Crook,Daniel S. Read,Muna F. Anjum,A. Sarah Walker,A. Sarah Walker,Nicole Stoesser +29 more
TL;DR: In this paper, the pangenome dynamics of natural populations remain understudied, despite their suggested role as reservoirs for antimicrobial resistance (AMR) genes, and the importance of local strategies for controlling the spread of AMR.