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Bernadette C. Young
Researcher at University of Oxford
Publications - 43
Citations - 2736
Bernadette C. Young is an academic researcher from University of Oxford. The author has contributed to research in topics: Staphylococcus aureus & Medicine. The author has an hindex of 18, co-authored 36 publications receiving 2068 citations. Previous affiliations of Bernadette C. Young include John Radcliffe Hospital.
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Journal ArticleDOI
Multilocus Sequence Typing of Clostridium difficile
David Griffiths,David Griffiths,Warren N. Fawley,Melina Kachrimanidou,Melina Kachrimanidou,Rory Bowden,Derrick W. Crook,Derrick W. Crook,Rowena Fung,Rowena Fung,Tanya Golubchik,Rosalind M. Harding,Katie Jeffery,Keith A. Jolley,Richard Kirton,Tim E. A. Peto,Tim E. A. Peto,Gareth Rees,Nicole Stoesser,Nicole Stoesser,Alison Vaughan,Alison Vaughan,A. Sarah Walker,A. Sarah Walker,Bernadette C. Young,Mark H. Wilcox,Kate E. Dingle,Kate E. Dingle +27 more
TL;DR: The MLST scheme was sufficiently robust to allow direct genotyping of C. difficile in total stool DNA extracts without isolate culture and may prove useful as a rapid genotypes method, potentially benefiting individual patients and informing hospital infection control.
Journal ArticleDOI
Prediction of Staphylococcus aureus Antimicrobial Resistance by Whole-Genome Sequencing
N C Gordon,James Price,Kevin Cole,Richard G. Everitt,Marcus Morgan,John Finney,Angela Kearns,Bruno Pichon,Bernadette C. Young,Daniel J. Wilson,Martin J. Llewelyn,John Paul,Tim E. A. Peto,Derrick W. Crook,A S Walker,Tanya Golubchik +15 more
TL;DR: WGS was as sensitive and specific as routine antimicrobial susceptibility testing methods and is a promising alternative to culture methods for resistance prediction in S. aureus and ultimately other major bacterial pathogens.
Journal ArticleDOI
Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease
Bernadette C. Young,Tanya Golubchik,Elizabeth M. Batty,Rowena Fung,Hanna Larner-Svensson,Antonina A. Votintseva,Ruth R. Miller,Heather Godwin,Kyle Knox,Richard G. Everitt,Zamin Iqbal,Andrew J. Rimmer,Madeleine Cule,Camilla L. C. Ip,Xavier Didelot,Rosalind M. Harding,Peter Donnelly,Tim E. A. Peto,Derrick W. Crook,Rory Bowden,Daniel J. Wilson +20 more
TL;DR: It is demonstrated that bacterial diversity in vivo is limited but nonetheless detectable by whole-genome sequencing, enabling the study of evolutionary dynamics within the host, and that clusters of protein-truncating mutations are highly unusual.
Journal ArticleDOI
Fidaxomicin versus vancomycin for Clostridium difficile infection: meta-analysis of pivotal randomized controlled trials.
Derrick W. Crook,Derrick W. Crook,A. Sarah Walker,A. Sarah Walker,Yin Kean,Karl Weiss,Oliver A. Cornely,Mark A. Miller,Roberto Esposito,Thomas J. Louie,Nicole Stoesser,Nicole Stoesser,Bernadette C. Young,Bernadette C. Young,Brian Angus,Sherwood L. Gorbach,Tim E. A. Peto,Tim E. A. Peto +17 more
TL;DR: Fidaxomicin has the potential to substantially improve outcomes from CDI and is shown to be noninferior to vancomycin for curing Clostridium difficile infection and superior for reducing CDI recurrences.
Journal ArticleDOI
Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study.
David W Eyre,Sheila F Lumley,Denise O'Donnell,Mark Campbell,Elizabeth Sims,Elaine Lawson,Fiona Warren,Tim James,Stuart Cox,Alison Howarth,George Doherty,Stephanie B Hatch,James Kavanagh,Kevin K Chau,Philip W. Fowler,Jeremy Swann,Denis Volk,Fan Yang-Turner,Nicole Stoesser,Philippa C Matthews,Maria Dudareva,Tim Davies,Robert Shaw,Leon Peto,Louise O Downs,Alexander Vogt,Ali Amini,Bernadette C. Young,Philip G. Drennan,Alexander J. Mentzer,Donal T. Skelly,Fredrik Karpe,Matt J. Neville,Monique Andersson,Andrew Brent,Nick S. Jones,L Martins Ferreira,Thomas Christott,Brian D. Marsden,Sarah Hoosdally,Richard J. Cornall,Derrick W. Crook,David I. Stuart,Gavin R. Screaton,T Peto,Bruno Holthof,O'Donnell A-M.,Daniel Ebner,Christopher P. Conlon,Katie Jeffery,Timothy M Walker +50 more
TL;DR: Risks were heterogenous across the hospital, with higher rates in acute medicine, and sporadic outbreaks in areas with few or no Covid-19 patients.